Agricultural water supplies are becoming increasingly uncertain in the western United States due to elevated demands from competing water users, environmental restrictions on surface water withdrawals as a result of the establishment of the Endangered Species Act in 1973, and potential climatic changes. Since many rural communities in the West...
Embryonic development, where organs and major structures begin to develop, requires precise coordination of numerous gene regulatory pathways. Fendrr is an long non-coding RNA (lncRNA) that plays a role in regulating gene expression in mesodermal tissues during early embryonic development in mouse. The lateral plate mesoderm (LPM) is an earlier...
This study examined two neighborhoods in San Francisco with similar earthquake-induced ground failure history -- the Marina District and the South of Market Area (SoMa) -- in the aftermath of the 1989 Loma Prieta earthquake. The earthquake struck shortly after 5 pm on October 17th, 1989 and registered 6.9 in...
The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...
Background: The uneven distribution of recombination across the length of chromosomes results in inaccurate estimates of genetic to physical distances. In wheat (Triticum aestivum L.) chromosome 3B, it has been estimated that 90% of the cross over events occur in distal sub-telomeric regions representing 40% of the chromosome. Radiation hybrid...
Nuclear pore complexes (NPCs) are huge assemblies formed from ~30 different nucleoporins, typically organized in subcomplexes. One module, the conserved Nup82 complex at the cytoplasmic face of NPCs, is crucial to terminate mRNA export. To gain insight into the structure, assembly, and function of the cytoplasmic pore filaments, we reconstituted...
As genome sequencing projects begin to come to completion, the challenge becomes one of determining how to understand the information contained within the DNA. DNA is a polymorphic macromolecule; the A- B- and Z-DNA conformations have been observed by a variety of physical techniques. The magnitude of the energetic differences...
Given k terminal pairs (s₁,t₁),(s₂,t₂),..., (s[subscript k],t[subscript k]) in an edge-weighted graph G, the k Shortest Vertex-Disjoint Paths problem is to find a collection P₁, P₂,..., P[subscript k] of vertex-disjoint paths with minimum total length, where P[subscript i] is an s[subscript i]-to-t[subscript i] path. As a special case of the...
A variable gain, high linearity, low power baseband filter for WLAN applications is implemented in a 1.5 V 3 V 0.15 μm CMOS process. This fourth-order low-pass filter, which is introduced in the transmit channel as a reconstruction filter between the D/A converter and the mixer, has a measured cut-off...
In a story of his life Les reflects on what he
has gained and what he has lost while seeking success in
the moving and shifting of military and academic life
through homes and schools all over the United States.
He describes himself as between races, languages, and
cultures.