Index Catalog // ScholarsArchive@OSU

Creator:: Miner, Jeffery N.
Abstract:: Vaccinia virus gene expression is characterized by tight temporal regulation. Viral early transcription begins within the cytoplasm upon infection; three hours later, early genes are repressed, DNA replication occurs and late gene expression commences. As an approach toward understanding the mechanisms governing vaccinia late gene expression, I have undertaken an...
Resource Type:: Dissertation
Full Text:: model for fundamental eukaryotic genetic processes, vaccinia seems particularly appropriate because

Creator:: Roseman, Nancy A.
Abstract:: Replication of vaccinia virus in the cytoplasm of the infected cell occurs under the direction of virally encoded gene products. Expression of approximately 200 viral genes follows a highly regulated temporal scheme which can be followed biochemically and morphologically during the assembly process. In order to dissect this complex genetic...
Resource Type:: Dissertation
Full Text:: process. In order to dissect this complex genetic program conditionally lethal mutants of vaccinia have

Creator:: Tamin, Azaibi
Abstract:: Several laboratories have shown that the VV replication cycle is dependent on the host cell nucleus. The basic biological observation is that if the host cell nucleus is physically removed by cytochalasin B-mediated enucleation, functionally inactivated by UV-irradiation, or selectively blocked with a-amanitin, the results are the same: W is...
Resource Type:: Dissertation
Full Text:: Molecular genetic analysis of vaccinia virus genes which

Creator:: Weinrich, Scott L.
Abstract:: The prototypal poxvirus vaccinia is a cytoplasmic-replicating DNA virus which contains a large genome with the capacity to encode 200 polypeptides. Tight temporal regulation coordinates the expression of this large number of genes throughout a relatively short replication cycle. As a first step towards identifying and understanding the regulatory mechanisms...
Resource Type:: Dissertation
Full Text:: Regulation of late gene expression in vaccinia virus AN

Creator:: Blouch, Robert Edward
Abstract:: L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus are produced. Previous studies have shown that the L1R protein is exclusively associated...
Resource Type:: Masters Thesis
Full Text:: Formation is Essential for Vaccinia Virus Late Protein LIR Function and for Production of Infectious

Creator:: Byrd, Chelsea M.
Abstract:: Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
Resource Type:: Dissertation
Full Text:: : Vaccinia Virus 17L Core Protein Proteinase Abstract approved: Dr. Dennis E. Vaccinia virus (VV) is a

Creator:: VanSlyke, Judy K.
Abstract:: Vaccinia virus (VV) is a large DNA virus belonging to the Orthopoxvirus family. The viral replicative life cycle takes place solely within the cytoplasm of a mammalian host cell. The VV genome contains 196 open reading frames which are expressed in a highly regulated and temporal fashion in order to...
Resource Type:: Dissertation
Full Text:: Proteolytic maturation of vaccinia virus structural

ScholarsArchive@OSU