Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
Full Text:
Lukens
6,7
, Mark Hickman
8
, Stephen Muench
1
, ShivKumarVerma
3
, Christopher R. Weber
2
Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
Full Text:
Capper5, Amanda K Lukens6,7, Mark Hickman8, Stephen Muench1,
ShivKumar Verma3, Christopher R. Weber2
Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
Full Text:
Lukens
6,7
, Mark Hickman
8
, Stephen Muench
1
, ShivKumarVerma
3
, Christopher R. Weber
2
Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. In this study, we characterized the effects of two novel biosynthetically engineered analogs of pactamycin, de-6MSA-7-demethyl-7- deoxypactamycin (TM-025) and 7-demethyl-7-deoxypactamycin (TM-026), in head and neck squamous cell carcinoma...
This research is aimed at obtaining a better understanding of the impact of the use of collaborative and simulation sessions for learning lean principles and methods. Study participants were enrolled in a Lean Manufacturing System Engineering (IE436/536) course at Oregon State University or at three other business and engineering universities...
This thesis outlines dominant ideologies and practices that affect women's authority in the urban social milieu of north India. Theories that consider the causes of social stratification by gender as well as social movement patterns are useful for understanding the durability of gender roles. The utility of these theories for...
Spectral profiles, transformed divergence values, and feature space derived from Landsat Thematic Mapper (TM) data were used to analyze the ability of four false color composites to discriminate between different classes of salt-affected soils. To compare the spatial distribution of salt-affected soil classes, maps were generated for each false color...
Temporal variations in surface ground temperature impart a signal to the subsurface thermal regime that is captured in borehole temperature-depth profiles. Seventy temperature-depth profiles in India, located between 12° and 28°N, are analyzed to infer past changes in ground temperature. These profiles exhibit predominantly positive anomalous temperatures relative to the...