The relative enrichment of skin sebaceous gland lipids with deuterium-labeled α-tocopherol was compared with plasma enrichment to evaluate the delivery of vitamin E to skin. For the first week of this study, each subject consumed a daily dose of deuterated vitamin E (150 mg of an equimolar mixture of RRR-α-[5-(C²H₃)]-(d₃)...
In rats, sesame lignans increase plasma γ-tocopherol concentrations and inhibit γ-tocopherol degradation to its metabolite γ-carboxyethylhydroxychroman (γ-CEHC). To test if sesame lignan consumption inhibits γ- tocopherol metabolism in humans, muffins prepared with either corn oil (control) or sesame oil and an equimolar mixture of deuterium labeled d6-α- and d2-γ- tocopheryl...
One group of four adult White Leghorn male chickens was fed a
diet containing 7.3% linoleic acid and 32.4 mg/ kg of added vitamin E
(group IV) for 50 weeks which was designated as the positive control.
A second lot (group I) containing 14 males received the same level of...
An in vitro study was conducted to investigate the metabolism and distribution of Se⁷⁵-selenite and Se⁷⁵-selenomethionine (SEM) in
chick blood. Se⁷⁵-selenite is taken up by RBC (13% within 20
minutes) and expelled into the plasma to become bound to proteins. In
contrast, Se⁷⁵-SEM showed a more gradual and continuous buildup...
Erythrocyte glutamic-pyruvic transaminase (EGPT) and
glutamic-oxaloacetic transaminase (EGOT) activities reflect
vitamin B₆ status in humans (Baysal, Johnson, and Linkswiler,
1966). Pyridoxal phosphate (PALPO), an active form
of vitamin B₆, serves as the coenzyme for these transaminases.
Compared to other methods of vitamin B₆ assessment,
transaminase measurement has the advantage of...
The primary goal of my study was to evaluate the effects of high dietary vitamin E on the rodent skeleton. The outcomes from my study assess the impact of high intakes of vitamin E and increased concentrations of its metabolite, carboxy ethyl hydroxy chromanol (CEHC), on bone turnover and skeletal...
Two lots of six White Leghorn male chickens were fed diets containing
7.3% linoleic acid and either .075% ethoxyquin (lot 1) or 32.4
mg/kg of added vitamin E (lot II) for 47 weeks both of which were
designated as positive controls. A third group (lot III) containing 30
males received...
Lipid peroxidation is believed to be an important
process in the development of cellular injury. In
addition to the degradation of biological membranes,
increasing evidence indicates that lipid peroxidation can
alter the structure and function of DMA.
The present study examines the peroxidation of
nuclear membranes and the capacity of...