Cell signaling is often mediated by protein-protein interactions, which must be specific, tunable, and transient to allow agile responsiveness to cellular messages. Due to their unique properties, multivalent, intrinsically disordered proteins make ideal candidates to accomplish these vital tasks. A single protein with multiple binding sites may bind numerous partners,...
Block 1 of the Averill Addition played an important
role in the early commercial development of Bandon, Oregon,
a town located on Oregon's south coast. Retail
establishments located on the block supplied the local
residents with a variety of merchandise for the period of
1886-1914.
During this period Bandon served...
The recent demand for wireless transceivers has created a flurry of research into nontraditional
receiver architectures. The homodyne receiver, because of its high degree of
integration, low complexity and low power consumption, has surfaced a desirable alternative
to the well-known heterodyne receiver. However, distortions such as gain and phase
imbalance...
Thermal decomposition of several di-p-toluenesulfonylhydrazones
was studied. It was found that the carbene decomposition
of tetramethyl-1,3-cyclobutanedione, di-p-toluenesulfonylhydrazone
gave two products resulting from
rearrangement. One was identified as 2,5-dimethyl-1,3,4-hexatriene. A tentative structure for the second was
proposed. During the course of the study, a more convenient
procedure for thermal decompositions was...
The semiconductor gallium arsenide (GaAs) has many potential
advantages over the more widely used semiconductor silicon (Si).
These include higher low field mobility, semi-insulating substrates,
a direct band-gap, and greater radiation hardness. All these
advantages offer distinct opportunities for implementation of new
circuit functions or extension of the operating conditions...
Transcription factors with multiple post-translational modifications (PTMs) are not uncommon, but comprehensive information on site-specific dynamics and interdependence is comparatively rare. Assessing dynamic changes in the extent of PTMs has the potential to link multiple sites both to each other and to biological effects observable on the same time scale....
Transcription factors comprise just over 7% of the human
proteome and serve as gatekeepers of cellular function,
integrating external signal information into gene expression programs that reconfigure cellular physiology at the
most basic levels. Surface-initiated cell signaling pathways converge on transcription factors, decorating these
proteins with an array of post-translational...