The purpose of this thesis is to determine if dietary and
metabolic relationships exist between cobalt and selenium. Two
groups of lambs were compared. The dams of one group of lambs
received an alfalfa hay adequate in selenium and the dams of the
other group received an alfalfa hay deficient...
In an attempt to find a laboratory species which develops an
experimental myopathy similar to white muscle disease (WMD) in
lambs, comparative studies of nutritional muscular dystrophy of
chicks were initiated. This condition was grossly visible as white
striations running parallel with the fibers of the pectoral muscles and
was...
White muscle disease or muscular dystrophy of sheep is a selenium
responsive malady common to many areas with an inherent natural
deficiency of selenium in the forage. The disease can be prevented in
lambs by adding trace amounts (approximately 0.1 ppm) of selenium to
the otherwise selenium deficient, forage fed...
Copper in blood and liver can be divided into several fractions.
Copper in blood is about evenly divided between erythrocytes and
plasma. Normal concentrations for most species range between one and
two parts per million. Plasma copper is mainly a copper protein,
ceruloplasmin and a loosely bound form, reacting directly...
The purpose of this thesis was (1) to determine a dietary regimen which would produce the greatest incidence of cardiac calcification in the cotton rat and (2) to determine the fatty acid composition of heart tissue.
Maximum incidence of cardiac calcification occurred from feeding torula yeast ration supplemented with 0.5%...
One hundred and fifty-one weanling rats of both sexes were fed
control diets or diets containing 160 ppm diethylnitrosamine (DEN) or
150 ppm N-2-fluorenyl-acetamide (FAA). The carcinogen level was
calculated so that the LD₅₀ should be achieved at about 17 weeks.
Each carcinogen treatment was incorporated with three different diet...
Selenomethionine and methionine have been postulated to be similarly
involved in protein synthesis. This thesis has evaluated this
hypothesis from a molecular and genetic approach. Selenomethionine
and methionine were incorporated into rabbit reticulocyte hemoglobin
at the same rates and in equal quantities. Each methionine demonstrated
competitive inhibition for its analog...