Changes in forest ecosystem conditions in the region have prompted federal resource agencies to target the health of ecosystems in an effort to learn more about cause and effect relationships, develop plans for restoring healthy forest conditions, and communicate with citizens about treatment alternatives and potential outcomes. Because of the...
Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an
expression level-dependent phenotype in transgenic rodents. We show that oral treatment with the therapeutic agent diacetyl-bis(4-methylthiosemicarbazonato)copper[superscript II] [Cu[superscript II](atsm)] increased the concentration of mutant SOD1 (SOD1G37R) in ALS model mice, but paradoxically improved locomotor...
