We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large intercompartmental backbones. The deviations were exaggerated in lamina-associated...
We investigated DNA methylomes of pediatric B-cell
acute lymphoblastic leukemias (B-ALLs) using
whole-genome bisulfite sequencing and high-definition
microarrays, along with RNA expression
profiles. Epigenetic alteration of B-ALLs occurred in
two tracks: de novo methylation of small functional
compartments and demethylation of large intercompartmental
backbones. The deviations were exaggerated
in lamina-associated...
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Lee, S. T., Muench, M. O., Fomin, M. E., Xiao, J., Zhou, M., de Smith, A., ... &
Wiemels, J. L. (2015