Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
Designing spectral efficient, high-speed wireless links that offer high quality-
of-service and range capability has been a critical research and engineering challenge. In this thesis, we mainly address the complexity and performance issues of
channel estimation and data detection in multiple-input multiple-output (MIMO)
orthogonal frequency division multiplexing (OFDM) systems over...
Parallel loops are one of the main sources of parallelism in scientific applications, and many parallel loops do not have a uniform iteration execution time. To achieve good performance for such applications on a parallel computer, iterations of a parallel loop have to be assigned to processors in such a...
Analysis of observations on sequential events over time is common in real life. Sequential measurements over time describing the behavior of systems are usually called time series data, which have been collected in a wide range of disciplines. Over the years there have been multiple research areas in studying stochastic...
We compare characteristics of electron impact ionization (EI) and multiphoton ionization (MPI) of doped super fluid helium droplets using the same droplet source. Selected dopant ion fragments from the two ionization schemes demonstrate different dependence on the doping pressure, which could be attributed to the different ionization mechanisms. While EI...
Intrinsically disordered protein (IDP) duplexes composed of two IDP chains cross-linked by bivalent partner proteins form scaffolds for assembly of multiprotein complexes. The N-terminal domain of dynein intermediate chain (N-IC) is one such IDP that forms a bivalent scaffold with multiple dynein light chains including LC8, a hub protein that...
In this dissertation, I describe the experimental investigation of large superfluid helium droplets. The goal and direction of this thesis is to facilitate the use of these droplets as part of our project ss-EDI. The overall scheme of ss-EDI is to dope proteins inside helium droplets and collect a diffraction...
Emerging evidence suggests that the tumor microenvironment plays a critical role in regulating cancer
stem cells (CSCs) and tumor progression through both autocrine and paracrine signaling. Elevated
production of bone morphogenetic proteins (BMPs) from human ovarian cancer cells and stroma has
been shown to increase CSC proliferation and tumor growth....
Physical activity is important for health. However, there is a lack of literature related to the physical activity levels of adults living in urban villagers, which is a vulnerable population in China. The aim of this study is to compare the physical activity and sedentary behavior engagements between urban villagers...
We propose the Breathing Earth System Simulator (BESS), an upscaling approach to quantify global gross primary productivity and evapotranspiration using MODIS with a spatial resolution of 1-5 km and a temporal resolution of 8 days. This effort is novel because it is the first system that harmonizes and utilizes MODIS...