Enantioenriched sp³-hybridized carbenoid reagents CR1R2MX (X = nucleofuge, M = electrofuge) of different types were investigated for the synthesis of polysubstituted alkyl chains by iterative stereospecific reagent-controlled homologation (StReCH) and for the stereospecific connective synthesis of alkenes by eliminative cross-coupling.
In the first part, putative enantioenriched α-chloroalkyllithiums (CHRLiCl) were employed...
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
Full Text:
Gottschalk15, Wei Tao16,
Jian Wang3,17, Jun Wang3,18, Xun Xu3, Harold Bae19, Marianne Nygaard20, Lene
The frequent misidentification of Asian garments in small museum collections indicated the need for a garment identification system specifically for use in differentiating the various forms of Asian clothing. The decision tree system proposed in this thesis is intended to provide an instrument to distinguish the clothing styles of Japan,...
Background: Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral
outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the
fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly.
Objectives: We examined potential associations between prenatal Hg exposure assessed...
Full Text:
et al. 2013; Hinners et al. 2012; Wickre
et al. 2004; Xun et al. 2013) have assessed
toenail Hg for
Gender relations as well as the social situation of Manchu women have long been ignored in studies of the cultural evolution of the Manchu. By setting the discussion of Manchu women in the context of cultural adaptation, this study reintroduces gender and women's problems into the research on the Manchu...
Three distinct methods to achieve the stereoselective synthesis of carbon-carbon bonds were investigated, encompassing: (i) the formation of axially chiral biaryl molecules by enantioselective Suzuki cross-coupling, (ii) the synthesis of α-phenylalkylboronic esters by enantioselective chain extension, and (iii) the stereospecific synthesis of alkenes by eliminative cross-coupling of enantioenriched sp³-hybridized carbenoids....
Besides enabling an enhanced mobile broadband access, fifth-generation (5G) wireless mobile networks are envisioned to support the connectivity of massive, heterogeneous Internet of Things (IoT) devices. Connecting these devices through 5G systems and providing them with their needed data rates require huge amounts of spectrum and power resources, thus calling...
The abilities of plant biologists to characterize the genetic basis of physiological traits are limited by their abilities to obtain quantitative data representing precise details of trait variation and mainly to collect this data on a high-throughput scale at low cost. Deep learning-based methods have demonstrated unprecedented potential to automate...
Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
In eukaryotes, ARGONAUTE proteins (AGOs) associate with microRNAs (miRNAs), short
interfering RNAs (siRNAs), and other classes of small RNAs to regulate target RNA or target
loci. Viral infection in plants induces a potent and highly specific antiviral RNA silencing
response characterized by the formation of virus-derived siRNAs. Arabidopsis thaliana has...