Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not
differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment
of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to
exceptionally...
Full Text:
., Bae, H., Schupf, N., Andersen, S., Zhang, Q., Perls, T., &
Sebastiani, P. (2015). Burden of disease
Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not
differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment
of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to
exceptionally...
Case control studies of nonagenarians and centenarians provide evidence that long‐lived individuals do not differ in the rate of disease associated variants compared to population controls. These results suggest that an enrichment of novel protective variants, rather than a lack of disease associated variants, determine the genetic predisposition to exceptionally...