This dissertation describes the racemic and enantioselective synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been an attractive synthetic target due to its intriguing structure: the macrocyclic core imparts sufficient strain on the system to force one benzene rings to adopt a boat-shaped conformation, out...
Natural products (secondary metabolites) are small organic molecules derived
from plants, microbes, and marine organisms that have served as a diverse source of
useful compounds pharmaceuticals. New biologically active natural products are critical
as anti-infective and cancer drug leads. Cyanobacteria, or blue-green algae, produce
diverse cytotoxic metabolites that represent potential...
Natural products (secondary metabolites) are small organic molecules derived
from plants, microbes, and marine organisms that have served as a diverse source of
useful compounds pharmaceuticals. New biologically active natural products are critical
as anti-infective and cancer drug leads. Cyanobacteria, or blue-green algae, produce
diverse cytotoxic metabolites that represent potential...
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Background and Relevance of Natural Products
Sample Collection by McPhail Lab
Goal of Project
New antibiotic compounds with novel mechanisms of action have become essential in response to the recent paradigm of increasingly resistant strains of bacteria. Secondary metabolites (natural products) from bacteria such as Actinobacteria serve as lead compounds for the development of pharmaceutical drugs widely used to fight bacterial, viral and fungal...
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Additive Part II: Discovery and Isolation of Bioactive Natural Products from Rare Non-Streptomyces
New antibiotic compounds with novel mechanisms of action have become essential in response to the recent paradigm of increasingly resistant strains of bacteria. Secondary metabolites (natural products) from bacteria such as Actinobacteria serve as lead compounds for the development of pharmaceutical drugs widely used to fight bacterial, viral and fungal...
Full Text:
Additive Part II: Discovery and Isolation of Bioactive Natural Products from Rare Non-Streptomyces
New antibiotic compounds with novel mechanisms of action have become essential in response to the recent paradigm of increasingly resistant strains of bacteria. Secondary metabolites (natural products) from bacteria such as Actinobacteria serve as lead compounds for the development of pharmaceutical drugs widely used to fight bacterial, viral and fungal...
Full Text:
. Nevertheless, focusing on improvement of
naturalproduct-based screening rather than high-throughput
Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
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secondary metabolites?
• Secondary metabolites, also called natural products, are molecules
produced by
Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
Full Text:
antibiotic, antitumor, and antiplasmodial activity. However, this naturalproduct has
not been developed
Doxorubicin hydrochloride (ADR) is an anthracycline antibiotic used to treat various cancers. However, due to its extensive cardiotoxic side effects a lifetime cumulative dose limit of 450–550 mg/m2 exists. The postulated mechanism of the cardiotoxicity is generation of reactive oxygen and nitrogen species. Natural products like resveratrol (RES), and quercetin...
Endophytes are bacteria or fungi that live within a host plant. The plant host provides a home for endophytes, and in return endophytes produce primary and secondary metabolites, of which many of the secondary metabolites possess biological activities. When microorganisms are grown under various media conditions, they produce different natural...
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, Oregon
NaturalProduct
2
Penicillin VK
“Natural products are
organic compounds that