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Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response Public Deposited

https://ir.library.oregonstate.edu/concern/articles/0k225c942

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  • Global change and its associated temperature increase has directly or indirectly changed the distributions of hosts and pathogens, and has affected host immunity, pathogen virulence and growth rates. This has resulted in increased disease in natural plant and animal populations worldwide, including scleractinian corals. While the effects of temperature increase on immunity and pathogen virulence have been clearly identified, their interaction, synergy and relative weight during pathogenesis remain poorly documented. We investigated these phenomena in the interaction between the coral Pocillopora damicornis and the bacterium Vibrio coralliilyticus, for which the infection process is temperature-dependent. We developed an experimental model that enabled unraveling the effects of thermal stress, and virulence vs. non-virulence of the bacterium. The physiological impacts of various treatments were quantified at the transcriptome level using a combination of RNA sequencing and targeted approaches. The results showed that thermal stress triggered a general weakening of the coral, making it more prone to infection, non-virulent bacterium induced an ‘efficient’ immune response, whereas virulent bacterium caused immuno-suppression in its host.
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  • Vidal-Dupiol, J., Dheilly, N. M., Rondon, R., Grunau, C., Cosseau, C., et al. (2014). Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response. PLoS ONE, 9(9), e107672. doi:10.1371/journal.pone.0107672
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  • This study was supported by the Agence Nationale de la Recherche through the Program BIOADAPT (ADACNI ANR-12-ADAP-0016-03) and the French-Israeli High Council for Science and Technology (P2R n °29702YG). Work in the Freitag laboratory was supported by start-up funds from the OSU Computational and Genome Biology Initiative and Oregon State University.
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  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2014-11-03T20:31:57Z (GMT) No. of bitstreams: 3 license_rdf: 1089 bytes, checksum: 0a703d871bf062c5fdc7850b1496693b (MD5) SmithKristinaBiochemBiophysThermalStressTriggers.pdf: 1071081 bytes, checksum: 582694a5f68676bfcdc66060f66586cd (MD5) SmithKristinaBiochemBiophysThermalStressTriggers_SupportingInformation.zip: 5320403 bytes, checksum: e323182a990916aeee66639cd593efd9 (MD5)
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