Acid-sensing ion channels in mouse olfactory bulb M/T neurons Public Deposited

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  • The olfactory bulb contains the first synaptic relay in the olfactory pathway, the sensory system in which odorants are detected enabling these chemical stimuli to be transformed into electrical signals and, ultimately, the perception of odor. Acid-sensing ion channels (ASICs), a family of proton-gated cation channels, are widely expressed in neurons of the central nervous system. However, no direct electrophysiological and pharmacological characterizations of ASICs in olfactory bulb neurons have been described. Using a combination of whole-cell patch-clamp recordings and biochemical and molecular biological analyses, we demonstrated that functional ASICs exist in mouse olfactory bulb mitral/tufted (M/T) neurons and mainly consist of homomeric ASIC1a and heteromeric ASIC1a/2a channels. ASIC activation depolarized cultured M/T neurons and increased their intracellular calcium concentration. Thus, ASIC activation may play an important role in normal olfactory function.
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  • Li, M. H., Liu, S. Q., Inoue, K., Lan, J., Simon, R. P., & Xiong, Z. G. (2014). Acid-sensing ion channels in mouse olfactory bulb M/T neurons. Journal of General Physiology, 143(6), 719-731. doi:10.1085/jgp.201310990
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  • 143
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  • 6
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  • The work in Z-.G. Xiong’s laboratory is supported in part by National Institutes of Health grants R01NS047506, R01NS066027, U54NS083932, NIMHD S21MD000101, AHA 0840132N, and ALZ IIRG-10-173350.
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