Article

 

Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention Public Deposited

Analytics
Default
https://ir.library.oregonstate.edu/concern/articles/1831cq610

This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Springer and can be found at:  http://link.springer.com/journal/12248.

Descriptions

Attribute NameValues
Creator
Abstract
  • Epidemiological evidence has demonstrated a reduced risk of prostate cancer associated with cruciferous vegetable intake. Follow-up studies have attributed this protective activity to the metabolic products of glucosinolates, a class of secondary metabolites produced by crucifers. The metabolic products of glucoraphanin and glucobrassicin, sulforaphane and indole-3-carbinol respectively, have been the subject of intense investigation by cancer researchers. Sulforaphane and indole-3-carbinol inhibit prostate cancer by both blocking initiation and suppressing prostate cancer progression in vitro and in vivo. Research has largely focused on the anti-initiation and cytoprotective effects of sulforaphane and indole-3-carbinol through induction of Phase I and Phase II detoxification pathways. With regards to suppressive activity, research has focused on the ability of sulforaphane and indole-3-carbinol to antagonize cell signaling pathways known to be dysregulated in prostate cancer. More recent investigations have characterized the ability of sulforaphane and indole-3-carbinol derivatives to modulate the activity of enzymes controlling the epigenetic status of prostate cancer cells. In this review we will summarize the well-established, “classic” non-epigenetic targets of sulforaphane and indole-3-carbinol, and highlight more recent evidence supporting these phytochemicals as epigenetic modulators for prostate cancer chemoprevention.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Watson, G. W., Beaver, L. M., Williams, D. E., Dashwood, R. H., & Ho, E. (2013). Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS Journal, 15(4), 951-961. doi:10.1208/s12248-013-9504-4
Journal Title
Journal Volume
  • 15
Journal Issue/Number
  • 4
Academic Affiliation
Keyword
Rights Statement
Funding Statement (additional comments about funding)
  • Our work is funded by NIH grants CA90890, CA65525, CA122906, CA122959, and CA80176 and by National Institute of Environmental Health Sciences (NIEHS) Center grant P30 ES00210.
Publisher
Peer Reviewed
Language
Replaces

Relationships

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
0r967881b?file=thumbnail HoEmilyPublicHealthHumanSciencesPhytochemicalsFromCruciferous.pdf 12/13/2017 Public
Hx11xm56v?file=thumbnail HoEmilyPublicHealthHumanSciencesPhytochemicalsFromCruciferousLegendToFigures.pdf 12/13/2017 Public
C534fv086?file=thumbnail HoEmilyPublicHealthHumanSciencesPhytochemicalsFromCruciferousFigure1.jpg 12/13/2017 Public
Ms35tf42j?file=thumbnail HoEmilyPublicHealthHumanSciencesPhytochemicalsFromCruciferousFigure2.jpg 12/13/2017 Public
Cj82kd264?file=thumbnail HoEmilyPublicHealthHumanSciencesPhytochemicalsFromCruciferousFigure3.jpg 12/13/2017 Public