Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy Public Deposited

http://ir.library.oregonstate.edu/concern/articles/1v53jz58n

This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by Dove Medical Press. The published article can be found at:  http://www.dovepress.com/international-journal-of-nanomedicine-journal.

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  • We report a novel cancer-targeted nanomedicine platform for imaging and prospect for future treatment of unresected ovarian cancer tumors by intraoperative multimodal phototherapy. To develop the required theranostic system, novel low-oxygen graphene nanosheets were chemically modified with polypropylenimine dendrimers loaded with phthalocyanine (Pc) as a photosensitizer. Such a molecular design prevents fluorescence quenching of the Pc by graphene nanosheets, providing the possibility of fluorescence imaging. Furthermore, the developed nanoplatform was conjugated with poly(ethylene glycol), to improve biocompatibility, and with luteinizing hormone-releasing hormone (LHRH) peptide, for tumor-targeted delivery. Notably, a low-power near-infrared (NIR) irradiation of single wavelength was used for both heat generation by the graphene nanosheets (photothermal therapy [PTT]) and for reactive oxygen species (ROS)-production by Pc (photodynamic therapy [PDT]). The combinatorial phototherapy resulted in an enhanced destruction of ovarian cancer cells, with a killing efficacy of 90%–95% at low Pc and low-oxygen graphene dosages, presumably conferring cytotoxicity to the synergistic effects of generated ROS and mild hyperthermia. An animal study confirmed that Pc loaded into the nanoplatform can be employed as a NIR fluorescence agent for imaging-guided drug delivery. Hence, the newly developed Pc-graphene nanoplatform has the significant potential as an effective NIR theranostic probe for imaging and combinatorial phototherapy.
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  • Taratula, O., Patel, M., Schumann, C., Naleway, M. A., Pang, A. J., He, H., & Taratula, O. (2015). Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy. International Journal of Nanomedicine, 10, 2347-2362. doi:10.2147/IJN.S81097
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  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2015-04-24T19:48:52Z (GMT) No. of bitstreams: 2 license_rdf: 1379 bytes, checksum: da3654ba11642cda39be2b66af335aae (MD5) TaratulaOlenaPharmacyPhthalocyanine-LoadedGraphene.pdf: 3253525 bytes, checksum: 6704de8680d2c2d6043eb6edca1e9632 (MD5)
  • description.provenance : Made available in DSpace on 2015-04-24T19:48:52Z (GMT). No. of bitstreams: 2 license_rdf: 1379 bytes, checksum: da3654ba11642cda39be2b66af335aae (MD5) TaratulaOlenaPharmacyPhthalocyanine-LoadedGraphene.pdf: 3253525 bytes, checksum: 6704de8680d2c2d6043eb6edca1e9632 (MD5) Previous issue date: 2015-03-24
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2015-04-24T19:48:34Z No. of bitstreams: 2 license_rdf: 1379 bytes, checksum: da3654ba11642cda39be2b66af335aae (MD5) TaratulaOlenaPharmacyPhthalocyanine-LoadedGraphene.pdf: 3253525 bytes, checksum: 6704de8680d2c2d6043eb6edca1e9632 (MD5)

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