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Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio)

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https://ir.library.oregonstate.edu/concern/articles/1v53jz82q

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Abstract
  • Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary intestinal chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other non-visceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.
  • This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American College of Veterinary Pathologists and published by Sage Publications. It can be found at: http://intl-vet.sagepub.com/.
  • Keywords: Zebrafish, Chordomas, Vertebral, Intestinal
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  • Cooper, T. K., Murray, K. N., Spagnoli, S., & Spitsbergen, J. M. (2015). Primary Intestinal and Vertebral Chordomas in Laboratory Zebrafish (Danio rerio). Veterinary Pathology, 52(2), 388-392. doi:10.1177/0300985814537531
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  • 52
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  • 2
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  • Parts of this work was funded by the US Public Health Service, National Institutes of Environmental Health Sciences (grants R01ES011587, R21ES013124, P30ESO3850, and P30ES00210); the National Center for Research Resources (grant 3P40RR12546 and its supplement 03S1); and the US Army (contract DAMD 17-91Z1043). The Zebrafish International Resource Center is supported by the National Institutes of Health Office of Research Infrastructure Programs. We would like to thank Amy Kugath and Drs. Shannon Fisher, Mary Mullins and Keith Cheng for contributing case I13, identified in a histologic phenotypic screen (NIH R01HD069321-01).
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