Compression of Coated Drug Beads for Sustained Release Tablet of Glipizide: Formulation, and Dissolution Public Deposited

http://ir.library.oregonstate.edu/concern/articles/37720j11d

This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Informa Healthcare and can be found at:  http://informahealthcare.com/phd.

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  • A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during dissolution testing while keeping the benefits of mulitparticular dosage forms. The tablets contain beads with four layers: the drug layer of 71.25 g of sugar beads overcoated with 2.5 g of glipizide and 3.75 g of solid ethylcellulose (Surelease®); the hardening layer of 5 g of hypromellose (HPMC); the controlled release layer of 7.5 g of ratio solid content of Surelease®:lactose = 100:7; and outmost layer of 20 g of lactose:sodium starch glycolate (Explotab®) = 2:1. Then beads were compressed into tablets containing 11mg of glipizide with 1500 pounds of compression pressure.
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  • Nguyen, C., Christensen, J., & Ayres, J. (2014). Compression of coated drug beads for sustained release tablet of glipizide: Formulation, and dissolution. Pharmaceutical Development and Technology, 19(1), 10-20. doi:10.3109/10837450.2012.751402
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