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Nelumbo Nucifera leaf extract attenuated pancreatic ß-cells toxicity induced by interleukin-1ß and interferon-γ, and increased insulin secrection of pancreatic ß-cells in streptozotocin-induced diabetic rats Public Deposited

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https://ir.library.oregonstate.edu/concern/articles/3f462734v

Open Access funded by Traditional Chinese Medicine Periodical Press.

This is the publisher’s final pdf. The article is published by Elsevier and copyrighted by China Association of Chinese Medicine. It can be found at:  http://www.sciencedirect.com/science/article/pii/S0254627216300115

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  • Objective: To evaluate the effect of Nelumbo Nucifera leaf water extract (NNLE) on insulinoma (RIN) cells induced by interleukin-1ß (IL-1ß) and interfer-on-g (IFN-γ), and injured pancreatic ß-cells induced by Streptozotocin (STZ) in rats. Methods: The anti-oxidative effects of NNLE were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) scavenging assays. The inhibitory effect of NNLE on α-glucosidase and DPP (dipeptidyl peptidase)-IV was measured in vitro. Pancreatic ß-cell protective and insulin secretory effects were assessed, using IL-1ß and IFN-γ-induced rat RIN cells. STZ-induced diabetic rats were treated with 50, 100, and 400 mg/kg NNLE for 4 weeks. The effects of NNLE on blood glucose (BG), body weight (BW), and lipid profiles were measured. Results: NNLE inhibited DPPH, NO, α-glucosidase, and DPP-IV which were directly linked to the function of ß-cells. Furthermore, NNLE protected RIN cells from toxicity induced by IL-1ß and IFN-γ, decreased NO production, and increased insulin secretion. NNLE caused a significant reduction in blood glucose, triglyceride (TG), total cholesterol (TC), blood urea nitrogen (BUN), and creatinine in STZ-induced diabetic rats. Furthermore, it significantly decreased BW loss in STZ-induced diabetic rats. Conclusion: Our results suggest that NNLE reduced the toxicity in insulinoma cells and increased insulin secretion in pancreatic ß-cells in STZ-induced diabetic rats.
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  • Sharma, B. R., Kim, M. S., & Rhyu, D. Y. (2016). Nelumbo Nucifera leaf extract attenuated pancreatic ß-cells toxicity induced by interleukin-1ß and interferon-γ, and increased insulin secrection of pancreatic ß-cells in streptozotocin-induced diabetic rats. Journal of Traditional Chinese Medicine, 36(1), 71-77.
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  • 36
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