A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control Public Deposited

http://ir.library.oregonstate.edu/concern/articles/4t64gp97m

This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by Public Library of Science. It can be found at:  http://journals.plos.org/plosntds/

Data Availability Statement: Data are publicly available on World Health Organization ( http://www. who.int/emergencies/zika-virus/situation-report/en/), Colombian Ministry of Health ( http://www.ins.gov.co/ Noticias/ZIKA/Forms/AllItems.aspx), and Brazilian Ministry of Health ( http://combateaedes.saude.gov.br/ situacao-epidemiologica) websites.

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  • Background: As Zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. For example, to combat the current Zika outbreak the US President requested the allocation of $1.8 billion from Congress in February 2016. Methodology/Principal Findings: Illustrated through an interactive tool, we evaluated how the number of Zika cases averted, the period during pregnancy in which Zika infection poses a risk of microcephaly, and probabilities of microcephaly and Guillain-Barré Syndrome (GBS) impact the cost at which an intervention is cost-effective. From Northeast Brazilian microcephaly incidence data, we estimated the probability of microcephaly in infants born to Zika-infected women (0.49% to 2.10%). We also estimated the probability of GBS arising from Zika infections in Brazil (0.02% to 0.06%) and Colombia (0.08%). We calculated that each microcephaly and GBS case incurs the loss of 29.95 DALYs and 1.25 DALYs per case, as well as direct medical costs for Latin America and the Caribbean of $91,102 and $28,818, respectively. We demonstrated the utility of our cost-effectiveness tool with examples evaluating funding commitments by Costa Rica and Brazil, the US presidential proposal, and the novel approach of genetically modified mosquitoes. Our analyses indicate that the commitments and the proposal are likely to be cost-effective, whereas the cost-effectiveness of genetically modified mosquitoes depends on the country of implementation. Conclusions/Significance: Current estimates from our tool suggest that the health burden from microcephaly and GBS warrants substantial expenditures focused on Zika virus control. Our results justify the funding committed in Costa Rica and Brazil and many aspects of the budget outlined in the US president’s proposal. As data continue to be collected, new parameter estimates can be customized in real-time within our user-friendly tool to provide updated estimates on costeffectiveness of interventions and inform policy decisions in country-specific settings.
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  • Alfaro-Murillo, J. A., Parpia, A. S., Fitzpatrick, M. C., Tamagnan, J. A., Medlock, J., Ndeffo-Mbah, M. L., ... & Galvani, A. P. (2016). A Cost-Effectiveness Tool for Informing Policies on Zika Virus Control. PLoS Neglected Tropical Diseases, 10(5), e0004743. doi:10.1371/journal.pntd.0004743
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  • description.provenance : Submitted by Open Access (openaccess@library.oregonstate.edu) on 2016-07-14T14:45:43Z No. of bitstreams: 2 AlfaroMurilloCostEffectivenessTool.PDF: 1112679 bytes, checksum: 53da50aa61be5cdef04c21ef0130d66b (MD5) AlfaroMurilloCostEffectivenessToolS1TableandS1-S2Figures.zip: 257992 bytes, checksum: e8b1dce423c3a8d1dfffc6f4824dfb73 (MD5)
  • description.provenance : Made available in DSpace on 2016-07-14T14:53:22Z (GMT). No. of bitstreams: 3 krauserp1458824901.zip: 1178810 bytes, checksum: 67ed487137ff11980a1a30570df361d3 (MD5) AlfaroMurilloCostEffectivenessTool.PDF: 1112679 bytes, checksum: 53da50aa61be5cdef04c21ef0130d66b (MD5) AlfaroMurilloCostEffectivenessToolS1TableandS1-S2Figures.zip: 257992 bytes, checksum: e8b1dce423c3a8d1dfffc6f4824dfb73 (MD5) Previous issue date: 2016-05
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2016-07-14T14:53:22Z (GMT) No. of bitstreams: 3 krauserp1458824901.zip: 1178810 bytes, checksum: 67ed487137ff11980a1a30570df361d3 (MD5) AlfaroMurilloCostEffectivenessTool.PDF: 1112679 bytes, checksum: 53da50aa61be5cdef04c21ef0130d66b (MD5) AlfaroMurilloCostEffectivenessToolS1TableandS1-S2Figures.zip: 257992 bytes, checksum: e8b1dce423c3a8d1dfffc6f4824dfb73 (MD5)

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