Article

 

AndersonKimEnvironmentalMolecularToxicologyBioaccessibilityOfMetals.pdf Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/articles/4x51hk916

Descriptions

Attribute NameValues
Creator
Abstract
  • Bioaccessibility in vitro tests measure the solubility of materials in surrogate biofluids. However, the lack of uniform methods and the effects of variable test parameters on material solubility limit interpretation. One aim of this study was to measure and compare bioaccessibility of selected economically important alloys and metals in surrogate physiologically based biofluids representing oral, inhalation and dermal exposures. A second aim was to experimentally test different biofluid formulations and residence times in vitro. A third aim was evaluation of dissolution behavior of alloys with in vitro lung and dermal biofluid surrogates. This study evaluated the bioaccessibility of sixteen elements in six alloys and 3 elemental/ metal powders. We found that the alloys/metals, the chemical properties of the surrogate fluid, and residence time all had major impacts on metal solubility. The large variability of bioaccessibility indicates the relevancy of assessing alloys as toxicologically distinct relative to individual metals.
Keyword
Rights Statement
Additional Information
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2014-08-14T20:34:46Z No. of bitstreams: 2 AndersonKimEnvironmentalMolecularToxicologyBioaccessibilityOfMetals.pdf: 477603 bytes, checksum: 4ab5c2cc17857afb94dc7ac0fdcca5df (MD5) AndersonKimEnvironmentalMolecularToxicologyBioaccessibilityOfMetalsSupplementaryData.pdf: 146992 bytes, checksum: b6e821d2bb92efd57e4857152d8f3393 (MD5)
  • description.provenance : Made available in DSpace on 2014-08-14T20:35:29Z (GMT). No. of bitstreams: 2 AndersonKimEnvironmentalMolecularToxicologyBioaccessibilityOfMetals.pdf: 477603 bytes, checksum: 4ab5c2cc17857afb94dc7ac0fdcca5df (MD5) AndersonKimEnvironmentalMolecularToxicologyBioaccessibilityOfMetalsSupplementaryData.pdf: 146992 bytes, checksum: b6e821d2bb92efd57e4857152d8f3393 (MD5) Previous issue date: 2014-02
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2014-08-14T20:35:29Z (GMT) No. of bitstreams: 2 AndersonKimEnvironmentalMolecularToxicologyBioaccessibilityOfMetals.pdf: 477603 bytes, checksum: 4ab5c2cc17857afb94dc7ac0fdcca5df (MD5) AndersonKimEnvironmentalMolecularToxicologyBioaccessibilityOfMetalsSupplementaryData.pdf: 146992 bytes, checksum: b6e821d2bb92efd57e4857152d8f3393 (MD5)

Relationships

Parents:

Items