Article

 

Tolerance and Efficacy of Emamectin Benzoate and Ivermectin for the Treatment of Pseudocapillaria tomentosa in Laboratory Zebrafish (Danio rerio) Público Deposited

Conteúdo disponível para baixar

Baixar PDF
https://ir.library.oregonstate.edu/concern/articles/5x21tk92r

Descriptions

Attribute NameValues
Creator
Abstract
  • Tolerance of adult zebrafish and efficacy of emamectin benzoate and ivermectin in eliminating Pseudocapillaria tomentosa infection were evaluated. In the tolerance study, behavioral changes, fecundity, histopathology, and mortality were evaluated for in-feed administration of emamectin (0.05, 0.10, and 0.25 mg/kg) and ivermectin (0.05 and 0.10 mg/kg). All doses of emamectin were well tolerated. Ivermectin 0.05 mg/kg administration resulted in mild behavioral changes and a transient decrease in fecundity. Ivermectin 0.10 mg/kg administration resulted in severe behavioral changes and some mortality. In the efficacy study, emamectin (0.05 and 0.25 mg/kg) and ivermectin (0.05 mg/kg) were evaluated for their efficacy in eliminating P. tomentosa infection. Emamectin reduced parasite burden in infected zebrafish, and ivermectin eliminated intestinal nematode infections. Despite a small margin of safety, ivermectin 0.05 mg/kg was effective at eliminating P. tomentosa infection in adult zebrafish. Higher doses or a longer course of treatment may be needed for complete elimination of P. tomentosa infection using emamectin. In this study, we propose two possible treatments for intestinal nematode infections in zebrafish.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Collymore, C., Watral, V., White, J. R., Colvin, M. E., Rasmussen, S., Tolwani, R. J., & Kent, M. L. (2014). Tolerance and Efficacy of Emamectin Benzoate and Ivermectin for the Treatment of Pseudocapillaria tomentosa in Laboratory Zebrafish (Danio rerio). Zebrafish, 11(5), 490-497. doi:10.1089/zeb.2014.1021
Journal Title
Journal Volume
  • 11
Journal Issue/Number
  • 5
Declaração de direitos
Funding Statement (additional comments about funding)
  • Various portions of this study were funded by Merck AnimalHealth, Comparative Bioscience Center of the RockefellerUniversity and grants from the National Institutes of HealthNIH 8R240D010998-11S.
Publisher
Peer Reviewed
Language
Replaces

Relações

Parents:

This work has no parents.

Itens