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Analysis of the genome of leporid herpesvirus 4

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https://ir.library.oregonstate.edu/concern/articles/6395w791d

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  • The genome of a herpesvirus highly pathogenic to rabbits, leporid herpesvirus 4 (LHV-4), was analyzed using high-throughput DNA sequencing technology and primer walking. The assembled DNA sequences were further verified by restriction endonuclease digestion and Southern blot analyses. The total length of the LHV-4 genome was determined to be about 124 kb. Genes encoded in the LHV-4 genome are most closely related to herpesvirus of the Simplexvirus genus, including human herpesviruses (HHV-1 and HHV-2), monkey herpesviruses including cercopithicine (CeHV-2 and CeHV-16), macacine (McHV-1), bovine herpesvirus 2 (BHV-2), and a lineage of wallaby (macropodid) herpesviruses (MaHV-1 and -2). Similar to other simplexvirus genomes, LHV-4 has a high overall G+C content of 65–70% in the unique regions and 75–77% in the inverted repeat regions. Orthologs of ICP34.5 and US5 were not identified in the LHV-4 genome. This study shows that LHV-4 has the smallest simplexvirus genome characterized to date.
  • Keywords: LHV-4, Genome, Sequencing
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  • Babra, B., Watson, G., Xu, W., Jeffrey, B. M., Xu, J., Rockey, D. D., . . . Jin, L. (2012). Analysis of the genome of leporid herpesvirus 4. Virology, 433(1), 183-191. doi: 10.1016/j.virol.2012.08.002
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  • 433
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  • 1
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  • This work was supported by NIH RO3AI080999 and the College of Veterinary Medicine at Oregon State University.
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