Zebrafish models for translational neuroscience research: from tank to bedside Public Deposited

http://ir.library.oregonstate.edu/concern/articles/6682x563p

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  • The zebrafish (Danio rerio) is emerging as a new important species for studying brain mechanisms and its deficits. Focusing on selected CNS disorders (brain cancer, epilepsy and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience, and their contribution to neuroimaging, circuit-level and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, we also summarize recent applications and existing challenges in this field. Finally, we emphasize the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes.
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  • Stewart, A. M., Braubach, O., Spitsbergen, J., Gerlai, R., & Kalueff, A. V. (2014). Zebrafish models for translational neuroscience research: from tank to bedside. Trends in Neurosciences, 37(5), 264-278. doi:10.1016/j.tins.2014.02.011
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  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2014-07-30T22:15:58Z No. of bitstreams: 1 SpitsbergenJanMicrobiologyZebrafishModelsTranslational.pdf: 1159200 bytes, checksum: 473927d715a72f07df5d0450c25fd44e (MD5)
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2014-07-30T22:16:29Z (GMT) No. of bitstreams: 1 SpitsbergenJanMicrobiologyZebrafishModelsTranslational.pdf: 1159200 bytes, checksum: 473927d715a72f07df5d0450c25fd44e (MD5)
  • description.provenance : Made available in DSpace on 2014-07-30T22:16:29Z (GMT). No. of bitstreams: 1 SpitsbergenJanMicrobiologyZebrafishModelsTranslational.pdf: 1159200 bytes, checksum: 473927d715a72f07df5d0450c25fd44e (MD5) Previous issue date: 2014-05

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