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Zebrafish models for translational neuroscience research: from tank to bedside

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Abstract
  • The zebrafish (Danio rerio) is emerging as a new important species for studying brain mechanisms and its deficits. Focusing on selected CNS disorders (brain cancer, epilepsy and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience, and their contribution to neuroimaging, circuit-level and drug discovery research. Outlining the role of zebrafish in modeling a wide range of human brain disorders, we also summarize recent applications and existing challenges in this field. Finally, we emphasize the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes.
  • Keywords: biomarkers, cancer, zebrafish, epilepsy, brain disorders, anxiety
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Citation
  • Stewart, A. M., Braubach, O., Spitsbergen, J., Gerlai, R., & Kalueff, A. V. (2014). Zebrafish models for translational neuroscience research: from tank to bedside. Trends in Neurosciences, 37(5), 264-278. doi:10.1016/j.tins.2014.02.011
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  • 37
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  • 5
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  • This research is supported by the National Institutes of Health/National Institute on Drug Abuse (NIH/NIDA) (A.V.K.), as well as by the NIH/National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the Natural Sciences and Engineering Research Council of Canada (NSERC) (R.G.).
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