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Informatics and Standards for Nanomedicine Technology Öffentlichkeit Deposited

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https://ir.library.oregonstate.edu/concern/articles/6d56zx29r

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  • There are several issues to be addressed concerning the management and effective use of information (or data), generated from nanotechnology studies in biomedical research and medicine. These data are large in volume, diverse in content, and are beset with gaps and ambiguities in the description and characterization of nanomaterials. In this work, we have reviewed three areas of nanomedicine informatics: information resources; taxonomies, controlled vocabularies, and ontologies; and information standards. Informatics methods and standards in each of these areas are critical for enabling collaboration; data sharing; unambiguous representation and interpretation of data; semantic (meaningful) search and integration of data; and for ensuring data quality, reliability, and reproducibility. In particular, we have considered four types of information standards in this article, which are standard characterization protocols, common terminology standards, minimum information standards, and standard data communication (exchange) formats. Currently, because of gaps and ambiguities in the data, it is also difficult to apply computational methods and machine learning techniques to analyze, interpret, and recognize patterns in data that are high dimensional in nature, and also to relate variations in nanomaterial properties to variations in their chemical composition, synthesis, characterization protocols, and so on. Progress toward resolving the issues of information management in nanomedicine using informatics methods and standards discussed in this article will be essential to the rapidly growing field of nanomedicine informatics.
  • This article is a U.S. Government work, and as such, is in the public domain in the United States of America.
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  • Thomas, D. G., Klaessig, F., Harper, S. L., Fritts, M., Hoover, M. D., Gaheen, S., Stokes, T. H., Reznik-Zellen, R., Freund, E. T., Klemm, J. D., Paik, D. S. and Baker, N. A. (2011), Informatics and standards for nanomedicine technology. WIREs Nanomed Nanobiotechnol, 3: 511–532. doi: 10.1002/wnan.152
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  • 3
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  • 5
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  • NAB and DGT acknowledge support from the NIH NCI caBIG® Working Group, Pacific Northwest National Laboratory HHS sector LDRD funds, as well as NIH grants U54 HG004028, U54 CA11934205, and U01 NS073457. SLH acknowledges support from NIH NCI caBIG® Working Group, Environmental Health and Sciences Center P30ES03850, EPA STAR RD-833320 and the Safer Nanomaterials and Nanomanufacturing Initiative of the Oregon Nanoscience and Microtechnologies Institute FA8650-05-1-5041.
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