Article

 

Impact of Study Design on the Evaluation of Inhaled and Intranasal Corticosteroids’ Effect on Hypothalamic–Pituitary–Adrenal Axis Function, Part I: General Overview of HPA Axis Study Design Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/articles/6d56zz28p

To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work. This is the publisher’s final pdf. The published article is copyrighted by Wiley Periodicals, Inc. and can be found at:  http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6017.

Descriptions

Attribute NameValues
Creator
Abstract
  • Inhaled and intranasal corticosteroids (ICS and INS) are among the mainstays of the treatment for asthma and allergic rhinitis, respectively, and also carry the potential to suppress the hypothalamic–pituitary–adrenal (HPA) axis. Several important factors affect the interpretability of trials investigating the impact of ICS and INS on the HPA axis. This paper reviews 106 published clinical trials, peer-reviewed articles, and New Drug Application reviews of approved ICS and INS, using MEDLINE and Drugs@FDA database. The trials included in this review evaluated the potential impact on HPA axis function of eight approved single-ingredient ICS and INS (beclomethasone dipropionate, budesonide, ciclesonide, flunisolide, fluticasone furoate, flucticasone propionate, mometasone furoate, and triamcinolone acetonide) and combination products containing these ingredients. The most commonly utilized design was blinded, placebo controlled, and short term (<6 weeks) for adult trials and blinded, placebo controlled, and long term (≥6 weeks) for pediatric trials. Factors potentially affecting trial results include the choice of dose, dosing duration, assay sensitivity, statistical methodology, and the study population evaluated (patients or healthy volunteers). All of these factors have the potential to affect the level of adrenal suppression detected. In conclusion, to be informative, a HPA axis study should be well designed and carefully implemented to minimize variability in results and improve the overall interpretability of data obtained.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Fan, Y., Ma, L., Pippins, J., Limb, S., Xu, Y., & Sahajwalla, C. G. (2013). Impact of Study Design on the Evaluation of Inhaled and Intranasal Corticosteroids’ Effect on Hypothalamic–Pituitary–Adrenal Axis Function, Part I: General Overview of HPA Axis Study Design. Journal of Pharmaceutical Sciences, 102(10), 3513-3527. doi:10.1002/jps.23689
Series
Keyword
Rights Statement
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Made available in DSpace on 2014-03-03T22:28:37Z (GMT). No. of bitstreams: 1 MaLianPharmacyImpactStudyDesign.pdf: 1127593 bytes, checksum: 156679a417ce6c27c7c990de504be6e2 (MD5) Previous issue date: 2013-10
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2014-03-03T16:04:46Z No. of bitstreams: 1 MaLianPharmacyImpactStudyDesign.pdf: 1127593 bytes, checksum: 156679a417ce6c27c7c990de504be6e2 (MD5)
  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2014-03-03T22:28:37Z (GMT) No. of bitstreams: 1 MaLianPharmacyImpactStudyDesign.pdf: 1127593 bytes, checksum: 156679a417ce6c27c7c990de504be6e2 (MD5)

Relationships

Parents:

This work has no parents.

Items