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Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression Public Deposited

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  • As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks.
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  • Rita Nahta, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Rafaela Andrade-Vieira, Sarah N. Bay, Dustin G. Brown, Gloria M. Calaf, Robert C. Castellino, Karine A. Cohen-Solal, Anna Maria Colacci, Nichola Cruickshanks, Paul Dent, Riccardo Di Fiore, Stefano Forte, Gary S. Goldberg, Roslida A. Hamid, Harini Krishnan, Dale W. Laird, Ahmed Lasfar, Paola A. Marignani, Lorenzo Memeo, Chiara Mondello, Christian C. Naus, Richard Ponce-Cusi, Jayadev Raju, Debasish Roy, Rabindra Roy, Elizabeth P. Ryan, Hosni K. Salem, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Renza Vento, Jan Vondráček, Mark Wade, Jordan Woodrick, William H. Bisson; Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression, Carcinogenesis, Volume 36, Issue Suppl_1, 1 June 2015, Pages S2–S18, https://doi.org/10.1093/carcin/bgv028
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  • 36
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  • Supp. 1
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  • Winship Cancer Institute (R.N.); FONDECYT (#1120006), MINEDUC(G.M.C.); NIH/NCI (R01CA172392 to R.C.C.); American CancerSociety (116683-RSG-09-087-01-TBE to K.C.-S.); Canadian BreastCancer Foundation and the Canadian Institute of Health Research(D.L., C.N.); Dalhousie Medical Research Foundation, BeatriceHunter Cancer Research Institute (P.M.); Czech Science Foundation(13-07711S to J.V.); Fondazione Cariplo (2011-0370 to C.M.); KuwaitInstitute for the Advancement of Sciences (2011-1302-06 toF. al-M.); Grant University Scheme (RUGs) Ministry of EducationMalaysia (04-02-12-2099RU to R.A.H.); Italian Ministry of Universityand Research (2009FZZ4XM_002 to A.A); the University of Florence(ex60%2012 to A.A.); US Public Health Service Grants (RO1 CA92306,RO1 CA92306-S1, RO1 CA113447 to R.R.); Department of Scienceand Technology, Government of India (SR/FT/LS-063/2008 to N.S.);Osteopathic Heritage Foundation to G.S.G.
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  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2015-07-15T16:03:42Z No. of bitstreams: 1 BissonWilliamHEnvironmentalMolecularToxicologyMechanismsEnvironmentalChemicals.pdf: 4464398 bytes, checksum: 61a911970c47c406670f4b03e040116a (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2015-07-15T17:41:48Z (GMT) No. of bitstreams: 1 BissonWilliamHEnvironmentalMolecularToxicologyMechanismsEnvironmentalChemicals.pdf: 4464398 bytes, checksum: 61a911970c47c406670f4b03e040116a (MD5)
  • description.provenance : Made available in DSpace on 2015-07-15T17:41:49Z (GMT). No. of bitstreams: 1 BissonWilliamHEnvironmentalMolecularToxicologyMechanismsEnvironmentalChemicals.pdf: 4464398 bytes, checksum: 61a911970c47c406670f4b03e040116a (MD5) Previous issue date: 2015-06

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