ECD of Tyrosine Phosphorylation in a Triple Quadrupole Mass Spectrometer with a Radio-Frequency-Free Electromagnetostatic Cell Public Deposited

http://ir.library.oregonstate.edu/concern/articles/6m311t83s

This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Society for Mass Spectrometry and published by Springer. It can be found at:  http://www.springer.com/chemistry/analytical+chemistry/journal/13361

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  • A radio frequency-free electromagnetostatic (EMS) cell devised for electron-capture dissociation (ECD) of ions has been retrofitted into the collision-induced dissociation (CID) section of a triple quadrupole mass spectrometer to enable recording of ECD product-ion mass spectra and simultaneous recording of ECD-CID product-ion mass spectra. This modified instrument can be used to produce easily interpretable ECD and ECD-CID product-ion mass spectra of tyrosine-phosphorylated peptides that cover over 50% of their respective amino-acid sequences and readily identify their respective sites of phosphorylation. ECD fragmentation of doubly protonated, tyrosine-phosphorylated peptides, which was difficult to observe with FT-ICR instruments, occurs efficiently in the EMS cell.
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  • Voinov, V. G., Bennett, S. E., Beckman, J. S., & Barofsky, D. F. (2014). ECD of Tyrosine Phosphorylation in a Triple Quadrupole Mass Spectrometer with a Radio-Frequency-Free Electromagnetostatic Cell. Journal of The American Society for Mass Spectrometry, 25(10), 1730-1738. doi:10.1007/s13361-014-0956-2
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