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Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity Public Deposited

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https://ir.library.oregonstate.edu/concern/articles/6q182k851

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  • Positively-charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.
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  • Smith, M. R., Boenzli, M. G., Hindagolla, V., Ding, J., Miller, J. M., Hutchison, J. E., . . . Bakalinsky, A. T. (2013). Identification of gold nanoparticle-resistant mutants of saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity. Applied and Environmental Microbiology, 79(2), 728-733. doi: 10.1128/AEM.01737-12
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  • 79
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  • 2
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  • This study was funded by U.S. Environmental Protection Agency (EPA) STAR program grant R833325 to A.T.B. The Oregon State University Environmental Health Sciences Center (grant number P30 ES000210; NIEHS, NIH) provided the library of yeast deletion mutants. The Safer Nanomaterials and Nanomanufacturing Initiative provided the AuNPs through a grant from the Air Force Research Laboratory under agreement number FA8650-05-1-5041. Additional funding was provided by the W. M. Keck Foundation.
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  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2013-03-30T00:36:19Z No. of bitstreams: 1 BakalinskyAlanFoodScienceTechnologyIdentificationGoldNanoparticle.pdf: 324539 bytes, checksum: bf915628dda771d8d06a1f011b848ed5 (MD5)
  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2013-03-30T00:37:40Z (GMT) No. of bitstreams: 1 BakalinskyAlanFoodScienceTechnologyIdentificationGoldNanoparticle.pdf: 324539 bytes, checksum: bf915628dda771d8d06a1f011b848ed5 (MD5)
  • description.provenance : Made available in DSpace on 2013-03-30T00:37:40Z (GMT). No. of bitstreams: 1 BakalinskyAlanFoodScienceTechnologyIdentificationGoldNanoparticle.pdf: 324539 bytes, checksum: bf915628dda771d8d06a1f011b848ed5 (MD5) Previous issue date: 2013-01

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