Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism Public Deposited

http://ir.library.oregonstate.edu/concern/articles/70795933g

Supplemental Information includes three figures, six tables, four files, and Supplemental Experimental Procedures and can be found with this article at  http://dx.doi.org/10.1016/j.chom.2016.01.002.

To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work. This is the publisher’s final pdf. The published article is copyrighted by Elsevier and can be found at:  http://www.cell.com/cell-host-microbe/home

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  • Pandemic influenza viruses modulate proinflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites, and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Integrative analysis of high-throughput omics data with virologic and histopathologic data uncovered relationships between host responses and phenotypic outcomes of viral infection. Proinflammatory lipid precursors in the trachea following 1918 infection correlated with severe tracheal lesions. Using an algorithm to infer cell quantity changes from gene expression data, we found enrichment of distinct T cell subpopulations in the trachea. There was also a predicted increase in inflammatory monocytes in the lung of 1918 virus-infected animals that was sustained throughout infection. This study presents a unique resource to the influenza research community and demonstrates the utility of an integrative systems approach for characterization of lipid metabolism alterations underlying respiratory responses to viruses.
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  • Tisoncik-Go, J., Gasper, D. J., Kyle, J. E., Eisfeld, A. J., Selinger, C., Hatta, M., ... & Katze, Michael G. (2016). Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism. Cell Host & Microbe, 19(2), 254-266. doi:10.1016/j.chom.2016.01.002
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  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2016-03-10T18:53:07Z (GMT) No. of bitstreams: 2 krauserp193219218.zip: 7808214 bytes, checksum: 9d3ace413ac1ae9b28f357ba0ba78100 (MD5) Tisoncik-GoIntegratedOmicsAnalysis.pdf: 8760251 bytes, checksum: 9b01d20951ff4c7f1028ccabb68576ff (MD5)
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