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The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling Public Deposited

https://ir.library.oregonstate.edu/concern/articles/7d278v632

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  • The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span.
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  • Engström, W., Darbre, P., Eriksson, S., Gulliver, L., Hultman, T., Karamouzis, M. V., ... & Bisson, W. H. (2015). The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis, 36(Suppl 1), S38-S60. doi:10.1093/carcin/bgv030
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  • Fondazione Cariplo (2011-0370 to C.M.); Kuwait Institute for the Advancement of Sciences (2011-1302-06 to F.A.-M.); Grant University Scheme (RUGs) Ministry of Education Malaysia (04- 02-12-2099RU to R.A.H.); Italian Ministry of University and Research (2009FZZ4XM_002 to A.A.); the University of Florence (2012 to A.A.); US Public Health Service Grants (RO1 CA92306, RO1 CA92306-S1, RO1 CA113447 to R.R.); Department of Science and Technology, Government of India (SR/FT/LS-063/2008 to N.S.); National Institute for Health Research Grant (II-ES-0511-21005); Nanosilver based catheters (to P.V.); Medical Research Council UK (MR/L007215/1 to A.W.); WEM Consulting (to T.H.); Getting to know cancer (to the entire team).
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  • description.provenance : Made available in DSpace on 2015-07-15T17:44:17Z (GMT). No. of bitstreams: 2 BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixtures.pdf: 2524390 bytes, checksum: a0e91400c4aadfa872d38e66c855e21b (MD5) BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixturesSupplementaryTables.pdf: 183430 bytes, checksum: ede439b4467a85063c3d513002b0aff6 (MD5) Previous issue date: 2015-06
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2015-07-15T17:44:17Z (GMT) No. of bitstreams: 2 BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixtures.pdf: 2524390 bytes, checksum: a0e91400c4aadfa872d38e66c855e21b (MD5) BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixturesSupplementaryTables.pdf: 183430 bytes, checksum: ede439b4467a85063c3d513002b0aff6 (MD5)
  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2015-07-15T16:31:45Z No. of bitstreams: 2 BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixtures.pdf: 2524390 bytes, checksum: a0e91400c4aadfa872d38e66c855e21b (MD5) BissonWilliamHEnvironmentalMolecularToxicologyPotentialChemicalMixturesSupplementaryTables.pdf: 183430 bytes, checksum: ede439b4467a85063c3d513002b0aff6 (MD5)

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