S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology Public Deposited

http://ir.library.oregonstate.edu/concern/articles/7w62fb24t

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  • Nitric oxide (NO) is an essential agent of the innate immune system which exhibits multi-mechanistic antimicrobial activity. Previously, increased antimicrobial activity against E. coli with nitric oxide releasing nanoparticles (NO-np) was demonstrated when combined with glutathione, versus NO-np alone, due to formation of S-nitrosoglutathione (GSNO), a potent transnitrosylating agent. To capitalize on this finding, the thiol-containing ACE-inhibitor, captopril, was incorporated into the NO-np system to form SNO-CAP-nps, nanoparticles that can both release NO as well as form S-nitrosocaptopril. SNO-CAP-nps demonstrated sustained release of NO and GSNO production in the presence of GSH over time. Both E. coli and MRSA were highly susceptible to SNO-CAP-np in a dose-dependent fashion, with E. coli being highly sensitive, while demonstrating no toxicity when exposed to zebrafish embryos. Given the significance of E. coli in urosepsis, as well as the ability of nanotechnology to overcome biofilm formation, SNO-CAP-np may prove useful against catheter-associated urinary tract infection.
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  • Mordorski, B., Pelgrift, R., Adler, B., Krausz, A., da Costa Neto, A. B., Liang, H., & Friedman, A. J. (2015). S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology. Nanomedicine: Nanotechnology, Biology and Medicine, 11(2), 283-291. doi:10.1016/j.nano.2014.09.017
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  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2016-06-29T23:19:54Z (GMT) No. of bitstreams: 2 bryan.harper@oregonstate.edu545327523.zip: 138723 bytes, checksum: 687aa68328bf684206adb4545a03431d (MD5) SNO-CAP paper - submitted.docx: 142252 bytes, checksum: 7a1f930136cf6e460824101c5a74690c (MD5)
  • description.provenance : Submitted by Open Access (openaccess@library.oregonstate.edu) on 2016-06-29T17:41:37Z No. of bitstreams: 1 SNO-CAP paper - submitted.docx: 142252 bytes, checksum: 7a1f930136cf6e460824101c5a74690c (MD5)
  • description.provenance : Made available in DSpace on 2016-06-29T23:19:54Z (GMT). No. of bitstreams: 2 bryan.harper@oregonstate.edu545327523.zip: 138723 bytes, checksum: 687aa68328bf684206adb4545a03431d (MD5) SNO-CAP paper - submitted.docx: 142252 bytes, checksum: 7a1f930136cf6e460824101c5a74690c (MD5) Previous issue date: 2015-02
  • description.peerreviewnotes : Mordorski, B., Pelgrift, R., Adler, B., Krausz, A., da Costa Neto, A. B., Liang, H., & Friedman, A. J. (2015). S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology. Nanomedicine: Nanotechnology, Biology and Medicine, 11(2), 283-291. doi:10.1016/j.nano.2014.09.017

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