Examining the Use of Ceftaroline in the Treatment of Streptococcus pneumoniae Meningitis with Reference to Human Cathelicidin LL-37 Public Deposited

http://ir.library.oregonstate.edu/concern/articles/8g84mn867

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  • Five cases of bacterial meningitis treated with ceftaroline (4 Streptococcus pneumoniae and 1 Staphylococcus aureus) are summarized here. The pharmacodynamics of human cathelicidin LL-37 and ceftaroline were evaluated against S. pneumoniae. Patients who received ceftaroline 600 mg every 8 h (q8h) (1 S. aureus and 3 S. pneumoniae) were successfully treated; treatment failed in 1 patient with S. pneumoniae who received 600 mg q12h. Ceftaroline increased the negative surface charge and sensitized S. pneumoniae to killing by LL-37, a peptide implicated in blood-brain barrier defense.
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  • Sakoulas, G., Nonejuie, P., Kullar, R., Pogliano, J., Rybak, M. J., & Nizet, V. (2015). Examining the Use of Ceftaroline in the Treatment of Streptococcus pneumoniae Meningitis with Reference to Human Cathelicidin LL-37. Antimicrobial agents and chemotherapy, 59(4), 2428-2431. doi:10.1128/AAC.04965-14
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  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2015-08-03T20:34:46Z No. of bitstreams: 1 KullarRavinaPharmacyExaminingUseCeftaroline.pdf: 627220 bytes, checksum: 6fe3cdc1ce100c6bfe976861562495f1 (MD5)
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  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2015-08-03T20:35:01Z (GMT) No. of bitstreams: 1 KullarRavinaPharmacyExaminingUseCeftaroline.pdf: 627220 bytes, checksum: 6fe3cdc1ce100c6bfe976861562495f1 (MD5)

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