Deoxyribonucleotides as Genetic and Metabolic Regulators Public Deposited

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  • For more than 35 years we have known that the accuracy of DNA replication is controlled in large part by the relative concentrations of the four canonical deoxyribonucleoside 5'-triphosphates (dNTPs) at the replisome. Since this field was last reviewed, about eight years ago, there has been increased understanding of the mutagenic pathways as they occur in living cells. At the same time, aspects of deoxyribonucleotide metabolism have been shown to be critically involved in processes as diverse as cell cycle control, protooncogene expression, cellular defense against HIV infection, replication rate control, telomere length control, and mitochondrial function. Evidence supports a relationship between dNTP pools and microsatellite repeat instability. Relationships between dNTP synthesis and breakdown in controlling steady-state pools have become better defined. In addition, new experimental approaches have allowed definitive analysis of mutational pathways induced by dNTP pool abnormalities, both in E. coli and in yeast. Finally, ribonucleoside triphosphate (rNTP) pools have been shown to be critical determinants of DNA replication fidelity. These developments are discussed in this review article.
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  • Mathews, C. K. (2014). Deoxyribonucleotides as genetic and metabolic regulators. The FASEB Journal, 28(9), 3832-3840. doi:10.1096/fj.14-251249
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  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2014-12-02T20:51:03Z (GMT) No. of bitstreams: 1 MathewsChristopherBiochemistryBiophysicsDeoxyribonucleotidesGeneticMetabolic.pdf: 444606 bytes, checksum: 3ab0f8e24f337ced2ba138fcf8d77788 (MD5)
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2014-12-02T20:50:16Z No. of bitstreams: 1 MathewsChristopherBiochemistryBiophysicsDeoxyribonucleotidesGeneticMetabolic.pdf: 444606 bytes, checksum: 3ab0f8e24f337ced2ba138fcf8d77788 (MD5)
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