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A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins Public Deposited

https://ir.library.oregonstate.edu/concern/articles/9s161785r

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  • Phytophthora pathogens secrete an array of specific effector proteins to manipulate host innate immunity to promote pathogen colonization. However, little is known about the host targets of effectors and the specific mechanisms by which effectors increase susceptibility. Here we report that the soybean pathogen Phytophthora sojae uses an essential effector PsAvh262 to stabilize endoplasmic reticulum (ER)-luminal binding immunoglobulin proteins (BiPs), which act as negative regulators of plant resistance to Phytophthora. By stabilizing BiPs, PsAvh262 suppresses ER stress-triggered cell death and facilitates Phytophthora infection. The direct targeting of ER stress regulators may represent a common mechanism of host manipulation by microbes.
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  • Jing, M., Guo, B., Li, H., Yang, B., Wang, H., Kong, G., ... & Wang, Y. (2016). A Phytophthora sojae effector suppresses endoplasmic reticulum stress-mediated immunity by stabilizing plant Binding immunoglobulin Proteins. Nature Communications, 7, 11685. doi:10.1038/ncomms11685
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  • 7
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  • This work is supported by the key program of National Natural Science Foundation Grant No. 31430073 and National Science Fund for Distinguished Young Scholars Grant No. 31225022 of China to Y.-C.W. from National Natural Science Foundation.
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