Biological screening of selected Pacific Northwest forest plants using the brine shrimp (Artemia salina) toxicity bioassay Public Deposited

http://ir.library.oregonstate.edu/concern/articles/9w0324957

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  • The brine shrimp (Artemia salina) bioassay was used to screen 211 methanol extracts from 128 species of Pacific Northwest plants in search of general cytotoxic activity. Strong toxicity (LC₅₀ < 100 µg/ml) was found for 17 extracts from 13 species, with highest activity observed for Angelica arguta roots at <10 µg/ml. Notably, four species of cedar trees and one of juniper in the family Cupressaceae dominated this group with LC₅₀ for heartwood extracts ranging from 15 to 89 µg/ml. Moderate toxicity (LC₅₀ 100–500 µg/ml) was found in 38 extracts from 27 species, while weak toxicity (LC₅₀ 500–1000 µg/ml) was detected for 17 extracts in 16 species. There were 139 extracts from 99 species that were non-toxic (LC₅₀ > 1000 µg/ml). Our subsequent studies of conifer heartwoods with strong activity confirm the assay’s value for identifying new investigational leads for materials with insecticidal and fungicidal activity.
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  • Karchesy, Y. M., Kelsey, R. G., Constantine, G., & Karchesy, J. J. (2016). Biological screening of selected Pacific Northwest forest plants using the brine shrimp (Artemia salina) toxicity bioassay. SpringerPlus, 5, 510. doi:10.1186/s40064-016-2145-1
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