Menage a trois: an evolutionary interplay between human papilloma virus, a tumor and a woman Public Deposited

http://ir.library.oregonstate.edu/concern/articles/b2773x48f

This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier and can be found at:  http://www.cell.com/trends/microbiology/home.

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  • Ménage à trois: an evolutionary interplay between human papillomavirus, a tumor, and a woman
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  • Cervical cancer is the third most common cancer in women with Human papillomavirus (HPV) being a key etiologic factor of this devastating disease. In this article, we describe modern advances in the genomics and transcriptomics of cervical cancer that led to uncovering the key gene drivers. We also introduce, herein, a Model of Cervical Carcinogenesis that explains how the interplay between virus, tumor and woman results in the selection of clones that simultaneously harbor genomic amplifications for genes that drive cell cycle, antiviral response, and inhibit cell differentiation. The new model may help understanding controversies in antiviral therapy and immunogenetics of this cancer and may provide a basis for future research directions in early diagnostics and personalization of therapy.
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  • Shulzhenko, N., Lyng, H., Sanson, G. F., & Morgun, A. (2014). Menage a trois: An evolutionary interplay between human papillomavirus, a tumor, and a woman. Trends in Microbiology, 22(6), 345-353. doi:10.1016/j.tim.2014.02.009
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