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Menage a trois : an evolutionary interplay between human papilloma virus, a tumor and a woman

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https://ir.library.oregonstate.edu/concern/articles/b2773x48f

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Abstract
  • Cervical cancer is the third most common cancer in women with Human papillomavirus (HPV) being a key etiologic factor of this devastating disease. In this article, we describe modern advances in the genomics and transcriptomics of cervical cancer that led to uncovering the key gene drivers. We also introduce, herein, a Model of Cervical Carcinogenesis that explains how the interplay between virus, tumor and woman results in the selection of clones that simultaneously harbor genomic amplifications for genes that drive cell cycle, antiviral response, and inhibit cell differentiation. The new model may help understanding controversies in antiviral therapy and immunogenetics of this cancer and may provide a basis for future research directions in early diagnostics and personalization of therapy.
  • Keywords: gene expression, immune response, genomic aberrations, network analysis, cervical cancer, human papillomavirus, driver genes
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  • Shulzhenko, N., Lyng, H., Sanson, G. F., & Morgun, A. (2014). Menage a trois: An evolutionary interplay between human papillomavirus, a tumor, and a woman. Trends in Microbiology, 22(6), 345-353. doi:10.1016/j.tim.2014.02.009
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  • 22
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  • 6
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