Comparative Pathology of Canine Soft Tissue Sarcomas: Possible Models of Human Non-rhabdomyosarcoma Soft Tissue Sarcomas Public Deposited

http://ir.library.oregonstate.edu/concern/articles/bc386k975

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  • Comparative analyses of canine and human soft tissue sarcomas (STSs) are lacking. This study compared the histological and immunohistochemical (labelling for desmin, smooth muscle actin [SMA], CD31, pancytokeratin, S100 and CD34) appearance of 32 archived, formalin-fixed, paraffin wax-embedded canine STS tumour specimens by board-certified veterinary and medical pathologists, both blinded to the other’s interpretations. Comparison between the veterinary and human diagnoses revealed a generally consistent pattern of interpretation with few notable variations. Most tumours (13/32) were judged to display similar histomorphological appearance to human low-grade spindle cell sarcomas, appearing non-distinctive and morphologically of a fibroblastic/myofibroblastic type. Five canine cases resembled human liposarcoma, but with atypical desmin-positive epithelioid cells present. Five canine cases resembled human spindle cell sarcoma with myxoid features and two additional cases resembled human myxofibrosarcoma. Seven canine cases were noted to resemble human undifferentiated sarcoma. Findings in the present study demonstrate that canine STSs display histological and immunohistochemical features similar to their human equivalents. Because of these cross-species similarities, a particular opportunity exists to understand the biology and treatment of human STS by potentially including dogs as clinical models.
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  • Milovancev, M., Hauck, M., Keller, C., Stranahan, L. W., Mansoor, A., & Malarkey, D. E. (2015). Comparative Pathology of Canine Soft Tissue Sarcomas: Possible Models of Human Non-rhabdomyosarcoma Soft Tissue Sarcomas. Journal of Comparative Pathology, 152(1), 22-27. doi:10.1016/j.jcpa.2014.09.005
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  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2015-04-16T19:40:56Z (GMT) No. of bitstreams: 2 MilovancevMilanVetMedComparativePathologyCanine.pdf: 349457 bytes, checksum: 47635ecfc8a9da2a2d931eef4aa331ca (MD5) MilovancevMilanVetMedComparativePathologyCanine_SupplementaryMaterials.zip: 7986744 bytes, checksum: 84de7213ba98c88a0b6e6f58bd4d1cca (MD5)
  • description.provenance : Made available in DSpace on 2015-04-16T19:40:56Z (GMT). No. of bitstreams: 2 MilovancevMilanVetMedComparativePathologyCanine.pdf: 349457 bytes, checksum: 47635ecfc8a9da2a2d931eef4aa331ca (MD5) MilovancevMilanVetMedComparativePathologyCanine_SupplementaryMaterials.zip: 7986744 bytes, checksum: 84de7213ba98c88a0b6e6f58bd4d1cca (MD5) Previous issue date: 2015-01
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2015-04-16T19:40:41Z No. of bitstreams: 2 MilovancevMilanVetMedComparativePathologyCanine.pdf: 349457 bytes, checksum: 47635ecfc8a9da2a2d931eef4aa331ca (MD5) MilovancevMilanVetMedComparativePathologyCanine_SupplementaryMaterials.zip: 7986744 bytes, checksum: 84de7213ba98c88a0b6e6f58bd4d1cca (MD5)

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