Accelerated food source location in aging Drosophila Public Deposited

http://ir.library.oregonstate.edu/concern/articles/df65v9543

Supporting information can be located at:  http://onlinelibrary.wiley.com/doi/10.1111/acel.12361/suppinfo

This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by John Wiley & Sons, Ltd. on behalf of the Anatomical Society. The published article can be found at:  http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291474-9726/

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  • Adequate energy stores are essential for survival, and sophisticated neuroendocrine mechanisms evolved to stimulate foraging in response to nutrient deprivation. Food search behavior is usually investigated in young animals, and it is not known how aging alters this behavior. To address this question in Drosophila melanogaster, we compared the ability to locate food by olfaction in young and old flies using a food-filled trap. As aging is associated with a decline in motor functions, learning, and memory, we expected that aged flies would take longer to enter the food trap than their young counterparts. Surprisingly, old flies located food with significantly shorter latency than young ones. Robust food search behavior was associated with significantly lower fat reserves and lower starvation resistance in old flies. Food-finding latency (FFL) was shortened in young wild-type flies that were starved until their fat was depleted but also in heterozygous chico mutants with reduced insulin receptor activity and higher fat deposits. Conversely, food trap entry was delayed in old flies with increased insulin signaling. Our results suggest that the difference in FFL between young and old flies is linked to age-dependent differences in metabolic status and may be mediated by reduced insulin signaling.
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  • Egenriether, S. M., Chow, E. S., Krauth, E. N. & Giebultowicz, J. M. (2015). Accelerated food source location in aging Drosophila. Aging Cell, 14(5), 916-918, doi:10.1111/acel.12361
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  • 14
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  • 5
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  • description.provenance : Made available in DSpace on 2015-09-30T17:33:26Z (GMT). No. of bitstreams: 2license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5)EgenrietherSadaIntegrativeBiologyAcceleratedFoodSource.pdf: 559732 bytes, checksum: 8ee697ecb9f4a559daff0327bdae2e6a (MD5) Previous issue date: 2015-10
  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2015-09-30T17:32:54ZNo. of bitstreams: 2license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5)EgenrietherSadaIntegrativeBiologyAcceleratedFoodSource.pdf: 559732 bytes, checksum: 8ee697ecb9f4a559daff0327bdae2e6a (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2015-09-30T17:33:25Z (GMT) No. of bitstreams: 2license_rdf: 1370 bytes, checksum: cd1af5ab51bcc7a5280cf305303530e9 (MD5)EgenrietherSadaIntegrativeBiologyAcceleratedFoodSource.pdf: 559732 bytes, checksum: 8ee697ecb9f4a559daff0327bdae2e6a (MD5)

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