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https://ir.library.oregonstate.edu/concern/articles/dn39x353k

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  • CONTEXT: In older adults with multiple conditions, medications may not impart the same benefits seen in patients who are younger, or without multi-morbidity. Furthermore, medications given for one condition may adversely affect other outcomes. Beta-blocker (β-Blocker) use with coexisting cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD) is such a situation. OBJECTIVE: To determine the effect of β-Blocker use on cardiac and pulmonary outcomes and mortality in older adults with coexisting COPD and CVD. DESIGN, SETTING, PARTICIPANTS: The 1062 participants were members of the 2004-2007 Medicare Current Beneficiary Survey cohorts, a nationally representative sample of Medicare beneficiaries. Study criteria included age 65+ years plus coexisting CVD and COPD/asthma. Follow-up occurred through 2009. We determined the association between β-Blocker use and the outcomes with propensity score-adjusted and covariate-adjusted Cox proportional hazards. MAIN OUTCOME MEASURES: The three outcomes were major cardiac and pulmonary events, and all-cause mortality. RESULTS: Half of the participants used β-Blockers. During follow-up 179 participants experienced a major cardiac event; 389 participants experienced a major pulmonary event; and 255 participants died. Each participant could have experienced any one or more of these events. The hazard ratio for β-blocker use was 1.18 (95% CI, 0.85-1.62) for cardiac events; 0.91 (95% CI, 0.73-1.12) for pulmonary events; and, 0.87 (95% CI, 0.67-1.13) for death. CONCLUSION: In this population of older adults, β-Blockers did not seem to affect occurrence of cardiac or pulmonary events or death in those with CVD and COPD.
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  • description.provenance : Approved for entry into archive by Deanne Bruner(deanne.bruner@oregonstate.edu) on 2014-09-03T00:43:09Z (GMT) No. of bitstreams: 6 LeeDavidSHPharmacyEffectBetaBlockers.pdf: 409711 bytes, checksum: a63359b56d8c6018bd01f0114bbb3e1f (MD5) LeeDavidSHPharmacyEffectBetaBlockers(Table1).pdf: 179989 bytes, checksum: bde3b58a0fa9e9b825b01b01b5ce1de0 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(Table2).pdf: 148727 bytes, checksum: 7e7cde1d295d83a2b4a8e71c5b9e7a89 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(MajorCardiacEvents).jpg: 813958 bytes, checksum: e9152f9980ed4e0d6a21bb4667e838c9 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(MajorPulmonaryEvents).jpg: 833659 bytes, checksum: c110bce5f6e05c431db87b9329187fdb (MD5) LeeDavidSHPharmacyEffectBetaBlockers(AllCauseMortality).jpg: 817009 bytes, checksum: 4a817ab6f3364eec2f6e60bd3712a4de (MD5)
  • description.provenance : Submitted by Deanne Bruner (deanne.bruner@oregonstate.edu) on 2014-09-03T00:39:51Z No. of bitstreams: 6 LeeDavidSHPharmacyEffectBetaBlockers.pdf: 409711 bytes, checksum: a63359b56d8c6018bd01f0114bbb3e1f (MD5) LeeDavidSHPharmacyEffectBetaBlockers(Table1).pdf: 179989 bytes, checksum: bde3b58a0fa9e9b825b01b01b5ce1de0 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(Table2).pdf: 148727 bytes, checksum: 7e7cde1d295d83a2b4a8e71c5b9e7a89 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(MajorCardiacEvents).jpg: 813958 bytes, checksum: e9152f9980ed4e0d6a21bb4667e838c9 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(MajorPulmonaryEvents).jpg: 833659 bytes, checksum: c110bce5f6e05c431db87b9329187fdb (MD5) LeeDavidSHPharmacyEffectBetaBlockers(AllCauseMortality).jpg: 817009 bytes, checksum: 4a817ab6f3364eec2f6e60bd3712a4de (MD5)
  • description.provenance : Made available in DSpace on 2014-09-03T00:43:09Z (GMT). No. of bitstreams: 6 LeeDavidSHPharmacyEffectBetaBlockers.pdf: 409711 bytes, checksum: a63359b56d8c6018bd01f0114bbb3e1f (MD5) LeeDavidSHPharmacyEffectBetaBlockers(Table1).pdf: 179989 bytes, checksum: bde3b58a0fa9e9b825b01b01b5ce1de0 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(Table2).pdf: 148727 bytes, checksum: 7e7cde1d295d83a2b4a8e71c5b9e7a89 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(MajorCardiacEvents).jpg: 813958 bytes, checksum: e9152f9980ed4e0d6a21bb4667e838c9 (MD5) LeeDavidSHPharmacyEffectBetaBlockers(MajorPulmonaryEvents).jpg: 833659 bytes, checksum: c110bce5f6e05c431db87b9329187fdb (MD5) LeeDavidSHPharmacyEffectBetaBlockers(AllCauseMortality).jpg: 817009 bytes, checksum: 4a817ab6f3364eec2f6e60bd3712a4de (MD5) Previous issue date: 2014-03