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Fabrication of a Flexible Amperometric Glucose Sensor Using Additive Processes

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https://ir.library.oregonstate.edu/concern/articles/f4752j37f

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  • This study details the use of printing and other additive processes to fabricate a novel amperometric glucose sensor. The sensor was fabricated using a Au coated 12.7 μm thick polyimide substrate as a starting material, where micro-contact printing, electrochemical plating, chloridization, electrohydrodynamic jet (e-jet) printing, and spin coating were used to pattern, deposit, chloridize, print, and coat functional materials, respectively. We have found that e-jet printing was effective for the deposition and patterning of glucose oxidase inks with lateral feature sizes between ∼5 to 1000 μm in width, and that the glucose oxidase was still active after printing. The thickness of the permselective layer was optimized to obtain a linear response for glucose concentrations up to 32 mM and no response to acetaminophen, a common interfering compound, was observed. The use of such thin polyimide substrates allow wrapping of the sensors around catheters with high radius of curvature ∼250 μm, where additive and microfabrication methods may allow significant cost reductions.
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  • Du, X., Durgan, C. J., Matthews, D. J., Motley, J. R., Tan, X., Pholsena, K., ... & Herman, G. S. (2015). Fabrication of a Flexible Amperometric Glucose Sensor Using Additive Processes. ECS Journal of Solid State Science and Technology, 4(4), P3069-P3074. doi:10.1149/2.0101504jss
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  • 4
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  • 4
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  • This research was funded by the National Institutes of Health (grant1-R43-DK-096678-01), the Leona M. and Harry B. Helmsley Charitable Trust (grant 2012PG_T1D034), and the Oregon Nanoscience and Microtechnologies Institute (ONAMI). X. Du acknowledges funding support from the Juvenile Diabetes Research Foundation (3-PDF-2014-113-A-N).
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