Article
 

Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the Polyp Prevention Trial

Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/articles/fj2362980

Descriptions

Attribute NameValues
Creator
Abstract
  • Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire, and adenoma recurrence in 1,859 participants of the Polyp Prevention Trial. Overall, individual or total lignans or proanthocyanidins were not associated with colorectal adenoma recurrence. However, in sex-specific analyses, total lignan intake was positively associated with any adenoma recurrence in women (highest vs. lowest lignan intake quartile OR = 2.07, 95% CI: 1.223.52, p trend = 0.004) but not in men (p interaction = 0.04). To conclude, dietary lignan and proanthocyanidin consumption were not generally related to colorectal adenoma recurrence; however, high lignan intake may increase the risk of adenoma recurrence in women.
  • This is the publisher’s final pdf. The published article is copyrighted by Wiley and can be found at: http://onlinelibrary.wiley.com/.
  • Keywords: Proanthocyanidins, Lignans, Cancer prevention, Colorectal cancer, Colorectal adenoma
Resource Type
DOI
Date Available
Date Issued
Citation
  • Bobe, G., Murphy, G., Albert, P. S., Sansbury, L. B., Lanza, E., Schatzkin, A., & Cross, A. J. (2012). Dietary lignan and proanthocyanidin consumption and colorectal adenoma recurrence in the polyp prevention trial. International Journal of Cancer. Journal International Du Cancer, 130(7), 1649-1659. doi: 10.1002/ijc.26184
Journal Title
Journal Volume
  • 130
Journal Issue/Number
  • 7
Rights Statement
Funding Statement (additional comments about funding)
  • Intramural Research Program, National Cancer Institute, NIH, DHHS (Bethesda, MD)
Publisher
Peer Reviewed
Language
Replaces

Relationships

Parents:

This work has no parents.

Items

Thumbnail Title Date Uploaded Visibility Actions
file details BobeGerdAnimalSciencesDietaryLignanProanthocyanidin.pdf 2017-07-13 Public Download