Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling Public Deposited

http://ir.library.oregonstate.edu/concern/articles/fj2364019

To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work. This is the publisher’s final pdf. The published article is copyrighted by Elsevier and can be found at:  http://www.journals.elsevier.com/bone.

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • Chronic heavy alcohol consumption is a risk factor for cortical bone fractures in males. The increase in fracture risk may be due, in part, to reduced bone quality. Intracortical (osteonal) bone remodeling is the principle mechanism for maintaining cortical bone quality. However, it is not clear how alcohol abuse impacts intracortical bone remodeling. This study investigated the effects of long-duration heavy alcohol consumption on intracortical bone remodeling in a non-human primate model. Following a 4-month induction period, male rhesus macaques (Macaca mulatta, n = 21) were allowed to voluntarily self-administer water or alcohol (4% ethanol w/v) for 22 h/d, 7 d/wk for 12 months. Control monkeys (n = 13) received water and an isocaloric maltose-dextrin solution. Tetracycline hydrochloride was administered orally 17 and 3 days prior to sacrifice for determination of active mineralization sites. Animals in the alcohol group consumed 2.7 ± 0.2 g alcohol/kg/d (mean ± SE) during the 12 months of self-administration, resulting in a mean daily blood alcohol concentration of 77 ± 9 mg/dl from samples taken at 7 h after the start of a daily session. However, blood alcohol concentration varied widely from day to day, with peak levels exceeding 250 mg/dl, modeling a binge-drinking pattern of alcohol consumption. The skeletal response to alcohol was determined by densitometry, microcomputed tomography and histomorphometry. Significant differences in tibial bone mineral content, bone mineral density, and cortical bone architecture (cross-sectional volume, cortical volume, marrow volume, cortical thickness, and polar moment of inertia) in the tibial diaphysis were not detected with treatment. However, cortical porosity was lower (1.8 ± 0.5 % versus 0.6 ± 0.1 %, p = 0.021) and labeled osteon density was lower (0.41 ± 0.2/mm² versus 0.04 ± 0.01/mm², p < 0.003) in alcohol-consuming monkeys compared to controls, indicating a reduced rate of intracortical bone remodeling. In concordance, plasma CTx was lower (2.5 ± 0.3 ng/ml versus 1.7 ± 0.1 ng/ml, p = 0.028) in the alcohol group. These results suggest that chronic heavy alcohol consumption may negatively impact bone health, in part, by suppressing intracortical bone remodeling.
Resource Type
DOI
Date Available
Date Issued
Citation
  • Gaddini, G. W., Grant, K. A., Woodall, A., Stull, C., Maddalozzo, G. F., Zhang, B., ... & Iwaniec, U. T. (2015). Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling. Bone, 71, 227-236. doi:10.1016/j.bone.2014.10.025
Series
Keyword
Rights Statement
Funding Statement (additional comments about funding)
Publisher
Peer Reviewed
Language
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2015-02-25T23:37:27Z (GMT) No. of bitstreams: 1 GaddiniGinoPHHSTwelveMonthsVoluntary.pdf: 1090725 bytes, checksum: 279fec186e9a7f9f269f02c91c9aa8d3 (MD5)
  • description.provenance : Made available in DSpace on 2015-02-25T23:37:27Z (GMT). No. of bitstreams: 1 GaddiniGinoPHHSTwelveMonthsVoluntary.pdf: 1090725 bytes, checksum: 279fec186e9a7f9f269f02c91c9aa8d3 (MD5) Previous issue date: 2015-02
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2015-02-25T23:37:12Z No. of bitstreams: 1 GaddiniGinoPHHSTwelveMonthsVoluntary.pdf: 1090725 bytes, checksum: 279fec186e9a7f9f269f02c91c9aa8d3 (MD5)

Relationships

Parents:

This work has no parents.

Last modified

Downloadable Content

Download PDF

Items