Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish Public Deposited

http://ir.library.oregonstate.edu/concern/articles/fq977w702

To the best of our knowledge, one or more authors of this paper were federal employees when contributing to this work. This is the publisher’s final pdf. The published article is copyrighted by Springer and can be found at:  http://link.springer.com/journal/10570

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  • Cellulose is an abundant and renewable resource currently being investigated for utility in nanomaterial form for various promising applications ranging from medical and pharmaceutical uses to mechanical reinforcement and biofuels. The utility of nanocellulose and wide implementation ensures increasing exposure to humans and the environment as nanocellulose-based technologies advance. Here, we investigate how differences in aspect ratio and changes to surface chemistry, as well as synthesis methods, influence the biocompatibility of nanocellulose materials using the embryonic zebrafish. Investigations into the toxicity of neutral, cationic and anionic surface functionalities revealed that surface chemistry had a minimal influence on the overall toxicity of nanocellulose materials. Higher aspect ratio cellulose nanofibers produced by mechanical homogenization were, in some cases, more toxic than other cellulose-based nanofibers or nanocrystals produced by chemical synthesis methods. Using fluorescently labeled nanocellulose we were able to show that nanocellulose uptake did occur in embryonic zebrafish during development. We conclude that the benign nature of nanocellulose materials makes them an ideal platform to systematically investigate the inherent surface features driving nanomaterial toxicity in order to create safer design principles for engineered nanoparticles.
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  • Harper, B. J., Clendaniel, A., Sinche, F., Way, D., Hughes, M., Schardt, J., ... & Harper, S. L. (2016). Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish. Cellulose, 23(3), 1763-1775.
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  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2016-06-28T20:34:35Z (GMT) No. of bitstreams: 1 HarperImpactsofChemicalModification.pdf: 1387315 bytes, checksum: d9040ecbc3b7682c89885a203a80d98e (MD5)
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  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2016-06-28T20:34:05Z No. of bitstreams: 1 HarperImpactsofChemicalModification.pdf: 1387315 bytes, checksum: d9040ecbc3b7682c89885a203a80d98e (MD5)

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