Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes Public Deposited

http://ir.library.oregonstate.edu/concern/articles/gt54kp66c

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  • Background: Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly. Objectives: We examined potential associations between prenatal Hg exposure assessed through infant toenail Hg, placental DNA methylation changes, and newborn neurobehavioral outcomes. Methods: The methylation status of > 485,000 CpG loci was interrogated in 192 placental samples using Illumina’s Infinium HumanMethylation450 BeadArray. Hg concentrations were analyzed in toenail clippings from a subset of 41 infants; neurobehavior was assessed using the NICU Network Neurobehavioral Scales (NNNS) in an independent subset of 151 infants. Results: We identified 339 loci with an average methylation difference > 0.125 between any two toenail Hg tertiles. Variation among these loci was subsequently found to be associated with a highrisk neurodevelopmental profile (omnibus p-value = 0.007) characterized by the NNNS. Ten loci had p < 0.01 for the association between methylation and the high-risk NNNS profile. Six of 10 loci reside in the EMID2 gene and were hypomethylated in the 16 high-risk profile infants’ placentas. Methylation at these loci was moderately correlated (correlation coefficients range, –0.33 to –0.45) with EMID2 expression. Conclusions: EMID2 hypomethylation may represent a novel mechanism linking in utero Hg exposure and adverse infant neurobehavioral outcomes.
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  • Maccani, J., Koestler, D. C., Lester, B., Houseman, E. A., Armstrong, D. A., Kelsey, K. T., & Marsit, C. J. (2015). Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes. Environmental Health Perspectives, 123(7), 723-729. doi:10.1289/ehp.1408561
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  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2015-08-24T17:54:39Z (GMT) No. of bitstreams: 3 Houseman EPublicHealthHumanSciPlacentalDNAMethylation.pdf: 1247825 bytes, checksum: 8a690088b7406de8282325a2446192ae (MD5) Houseman EPublicHealthHumanSciPlacentalDNAMethylationSupplementalMaterial.pdf: 1476913 bytes, checksum: 562cbb6090ed94242c1e2de3285a8385 (MD5) Houseman EPublicHealthHumanSciPlacentalDNAMethylationSupplementalMaterialTableContents.pdf: 118692 bytes, checksum: afee98b34711ea24dd763b54a248a85a (MD5)
  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2015-08-24T17:54:11Z No. of bitstreams: 3 Houseman EPublicHealthHumanSciPlacentalDNAMethylation.pdf: 1247825 bytes, checksum: 8a690088b7406de8282325a2446192ae (MD5) Houseman EPublicHealthHumanSciPlacentalDNAMethylationSupplementalMaterial.pdf: 1476913 bytes, checksum: 562cbb6090ed94242c1e2de3285a8385 (MD5) Houseman EPublicHealthHumanSciPlacentalDNAMethylationSupplementalMaterialTableContents.pdf: 118692 bytes, checksum: afee98b34711ea24dd763b54a248a85a (MD5)
  • description.provenance : Made available in DSpace on 2015-08-24T17:54:39Z (GMT). No. of bitstreams: 3 Houseman EPublicHealthHumanSciPlacentalDNAMethylation.pdf: 1247825 bytes, checksum: 8a690088b7406de8282325a2446192ae (MD5) Houseman EPublicHealthHumanSciPlacentalDNAMethylationSupplementalMaterial.pdf: 1476913 bytes, checksum: 562cbb6090ed94242c1e2de3285a8385 (MD5) Houseman EPublicHealthHumanSciPlacentalDNAMethylationSupplementalMaterialTableContents.pdf: 118692 bytes, checksum: afee98b34711ea24dd763b54a248a85a (MD5) Previous issue date: 2015-07

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