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Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies Public Deposited

https://ir.library.oregonstate.edu/concern/articles/h128ng398

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Abstract
  • SCOPE: Aim of the study was to identify and monitor metabolite markers of dry bean consumption in parallel human and mouse studies that each had shown chemopreventive effects of dry bean consumption on colorectal neoplasia risk. METHODS and RESULTS: Using LC/mass spectroscopy ± ESI and GC/mass spectroscopy, serum metabolites of dry beans were measured in 46 men before and after a 4-week dry bean enriched diet (250 g/day) and 12 mice that received a standardized diet containing either 0 or 10% navy bean ethanol extract for 6 weeks; we also investigated fecal metabolites in the mice. The serum metabolites identified in these controlled feeding studies were then investigated in 212 polyp-free participants from the Polyp Prevention Trial who self-reported either increased (≥+31 g/day from baseline), high dry bean intake of ≥42 g/day in year 3 or low, unchanged dry bean consumption of <8 g/day; serum was analyzed from baseline and year 3. Serum pipecolic acid and S-methyl cysteine were elevated after dry bean consumption in human and mouse studies and reflected dry bean consumption in the Polyp Prevention Trial. CONCLUSION: Serum levels of pipecolic acid and S-methyl cysteine are useful biomarkers of dry bean consumption.
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  • Perera, T., Young, M. R., Zhang, Z., Murphy, G., Colburn, N. H., Lanza, E., ... & Bobe, G. (2015). Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies. Molecular Nutrition & Food Research, 59(4), 795-806. doi:10.1002/mnfr.201400847
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  • 59
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  • 4
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  • This study was funded by the Office of Complementary and Alternative Medicine, the Office of Dietary Supplements, the US Dry Bean Council, Oregon State University, the General Research Center at Penn State University (NIH grant M01 RR10732), and the Intramural Research Program, National Cancer Institute, NIH, DHHS, Bethesda, MD (Z01 CP10198-08; ZIA BC 010025; subcontract 25XS101).
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  • description.provenance : Approved for entry into archive by Erin Clark(erin.clark@oregonstate.edu) on 2015-05-20T17:26:13Z (GMT) No. of bitstreams: 2 BobeGerdAnimalRangelandSciIdentificationMonitoringMetabolite.pdf: 1600409 bytes, checksum: 7fd74b2dcd2f642c5bd0f13876dd1e67 (MD5) BobeGerdAnimalRangelandSciIdentificationMonitoringMetabolite_SupportingInformation.pdf: 8707 bytes, checksum: c18de9ccb157ef207c2eb28e862abd80 (MD5)
  • description.provenance : Submitted by Erin Clark (erin.clark@oregonstate.edu) on 2015-05-20T17:25:59Z No. of bitstreams: 2 BobeGerdAnimalRangelandSciIdentificationMonitoringMetabolite.pdf: 1600409 bytes, checksum: 7fd74b2dcd2f642c5bd0f13876dd1e67 (MD5) BobeGerdAnimalRangelandSciIdentificationMonitoringMetabolite_SupportingInformation.pdf: 8707 bytes, checksum: c18de9ccb157ef207c2eb28e862abd80 (MD5)
  • description.provenance : Made available in DSpace on 2015-05-20T17:26:13Z (GMT). No. of bitstreams: 2 BobeGerdAnimalRangelandSciIdentificationMonitoringMetabolite.pdf: 1600409 bytes, checksum: 7fd74b2dcd2f642c5bd0f13876dd1e67 (MD5) BobeGerdAnimalRangelandSciIdentificationMonitoringMetabolite_SupportingInformation.pdf: 8707 bytes, checksum: c18de9ccb157ef207c2eb28e862abd80 (MD5) Previous issue date: 2015-04

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