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Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

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https://ir.library.oregonstate.edu/concern/articles/h415pb33n

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  • Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver. However, there was a marked increase in ovarian tumors (females) and hyperplastic testes (males). [¹⁴C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [¹⁴C] 3 weeks post dose. This study highlights the importance of developmental stage in susceptibility to environmental carcinogens.
  • This is the author's peer reviewed final manuscript as accepted by the publisher. The published article is copyrighted by Elsevier and can be found here: http://www.elsevier.com/wps/find/journaldescription.cws_home/506050/description#description
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  • L. Shorey, D.J. Castro, W. Baird, B. Siddens, C. Löhr, M. Matzke, K.M. Waters, R.A.Corley, D.E. Williams, Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of MaternalExposures Determines Target Tissue Response in Offspring, Cancer Letters (2011), doi: 10.1016/j.canlet.2011.11.010
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  • 317
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  • 1
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  • Support from this study was provided by the following PHS grants from NIH, P42 ES016465, P01 CA90890, T32ES07060 and P30 ES03850 along with assistance from The Linus Pauling Institute at Oregon State University.
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