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Environmental immune disruptors, inflammation and cancer risk Public Deposited

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  • An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is despite the well-recognized role that innate and adaptive immunity play as essential factors in tumorigenesis. Here, we review the role that the innate immune cells of inflammatory responses play in tumorigenesis. Focus is placed on the molecules and pathways that have been mechanistically linked with tumor-associated inflammation. Within the context of chemically induced disturbances in immune function as co-factors in carcinogenesis, the evidence linking environmental toxicant exposures with perturbation in the balance between pro- and anti-inflammatory responses is reviewed. Reported effects of bisphenol A, atrazine, phthalates and other common toxicants on molecular and cellular targets involved in tumor-associated inflammation (e.g. cyclooxygenase/prostaglandin E₂ , nuclear factor kappa B, nitric oxide synthesis, cytokines and chemokines) are presented as example chemically mediated target molecule perturbations relevant to cancer. Commentary on areas of additional research including the need for innovation and integration of systems biology approaches to the study of environmental exposures and cancer causation are presented.
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  • Thompson, P. A., Khatami, M., Baglole, C. J., Sun, J., Harris, S., Moon, E. Y., ... & Bisson, W. H. (2015). Environmental immune disruptors, inflammation and cancer risk. Carcinogenesis, 36(Suppl 1), S232-S253. doi:10.1093/carcin/bgv038
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  • 36
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  • Supp. 1
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  • National Institute of Environmental Health Sciences (P30ES000210 to W.H.B.). T.G. was supported by a grant from Fundamental OrientedResearch (RFO) to the Alma Mater Studiorum University ofBologna, Bologna, Italy and thanks the Fondazione Cassa diRisparmio di Bologna and the Fondazione Banca del Montedi Bologna e Ravenna for supporting the Center for AppliedBiomedical Research, S.Orsola-Malpighi University Hospital,Bologna, Italy.
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  • description.provenance : Made available in DSpace on 2015-07-15T20:10:33Z (GMT). No. of bitstreams: 1 BissonWilliamHEnvironmentalMolecularToxicologyEnvironmentalImmuneDisruptors.pdf: 3231332 bytes, checksum: 7d405da32ecf84c20bee5e0b08cf4ff5 (MD5) Previous issue date: 2015-06
  • description.provenance : Submitted by Patricia Black (patricia.black@oregonstate.edu) on 2015-07-15T20:10:05Z No. of bitstreams: 1 BissonWilliamHEnvironmentalMolecularToxicologyEnvironmentalImmuneDisruptors.pdf: 3231332 bytes, checksum: 7d405da32ecf84c20bee5e0b08cf4ff5 (MD5)
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2015-07-15T20:10:33Z (GMT) No. of bitstreams: 1 BissonWilliamHEnvironmentalMolecularToxicologyEnvironmentalImmuneDisruptors.pdf: 3231332 bytes, checksum: 7d405da32ecf84c20bee5e0b08cf4ff5 (MD5)

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